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RNF138 Antibody

  • 货号：
    CSB-PA994526
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from MCF-7 cells, using RNF138 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RNF138 Polyclonal antibody
  • Uniprot No.：
    Q8WVD3
  • 基因名：
    RNF138
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human RNF138.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
  • 基因功能参考文献：
    1. Study suggested that RNF138 was important for the proliferation, migration and invasion of glioma cells. Its downregulation inhibited the process of EMT by suppressing Erk signaling pathway in glioma. PMID: 30272353
    2. This study identify RNF138 as the E3 ubiquitin ligase promoting EA2-associated aberrant degradation of human CaV2.1 protein. PMID: 28167673
    3. Rad51d mediated by E3 Ligase Rnf138 has a role in the homologous recombination repair pathway PMID: 27195665
    4. RNF138 is a newly identified regulatory component of the HR mediated DNA repair pathway that has implications toward understanding how ubiquitination modifies the functions of the RAD51 paralog protein complex PMID: 27161866
    5. Data show that ubiquitin E3 ligase RNF138 regulates Ku80 antigen ubiquitylation in response to DNA damage. PMID: 26502055
    6. Data show that ubiquitin E2 enzymes UBE2D1/2/3 and E3 ligase RNF138 accumulate at DNA-damage sites and act at early resection stages by promoting CtIP protein ubiquitylation and accrual. PMID: 26502057
    7. The RNF138 gene is highly expressed in glioma tissue and glioma cell lines and plays an important role in glioma cell proliferation, apoptosis, and cell cycle. PMID: 22155992

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  • 亚细胞定位：
    Chromosome.
  • 数据库链接：

    HGNC: 17765

    OMIM: 616319

    KEGG: hsa:51444

    STRING: 9606.ENSP00000261593

    UniGene: Hs.302408