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RNF26 Antibody

  • 货号:
    CSB-PA019883LA01HU
  • 规格:
    ¥440
  • 促销:
    小规格抗体限时一口价
  • 图片:
    • Western blot
      All lanes: RNF26 antibody at 6µg/ml + 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 48 kDa
      Observed band size: 48 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA019883LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA019883LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA019883LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

产品详情

  • 产品名称:
    Rabbit anti-Homo sapiens (Human) RNF26 Polyclonal antibody
  • Uniprot No.:
    Q9BY78
  • 基因名:
    RNF26
  • 别名:
    RNF26; E3 ubiquitin-protein ligase RNF26; RING finger protein 26
  • 宿主:
    Rabbit
  • 反应种属:
    Human
  • 免疫原:
    Recombinant Human E3 ubiquitin-protein ligase RNF26 protein (246-433AA)
  • 免疫原种属:
    Homo sapiens (Human)
  • 标记方式:
    Non-conjugated

    本页面中的产品,RNF26 Antibody (CSB-PA019883LA01HU),的标记方式是Non-conjugated。对于RNF26 Antibody,我们还提供其他标记。见下表:

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA019883LB01HU RNF26 Antibody, HRP conjugated ELISA
    FITC CSB-PA019883LC01HU RNF26 Antibody, FITC conjugated
    Biotin CSB-PA019883LD01HU RNF26 Antibody, Biotin conjugated ELISA
  • 克隆类型:
    Polyclonal
  • 抗体亚型:
    IgG
  • 纯化方式:
    >95%, Protein G purified
  • 浓度:
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式:
    Liquid
  • 应用范围:
    ELISA, WB, IHC, IF
  • 推荐稀释比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 储存条件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能:
    E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3.
  • 基因功能参考文献:
    1. Study reveals the endoplasmic reticulum (ER)-located ubiquitin ligase Ring finger protein 26 (RNF26) as the global architect of the entire endosomal system, including the trans-Golgi network. PMID: 27368102
  • 亚细胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 组织特异性:
    Ubiquitous. Up-regulated in several cancer cell lines.
  • 数据库链接:

    HGNC: 14646

    OMIM: 606130

    KEGG: hsa:79102

    UniGene: Hs.524084