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RNF41 Antibody

  • 货号：
    CSB-PA880976ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: RNF41 antibody at 5.55 μg/ml + Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 36, 28 kDa
      Observed band size: 36, 50, 55 kDa
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA880976ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA880976ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RNF41 Polyclonal antibody
  • Uniprot No.：
    Q9H4P4
  • 基因名：
  • 别名：
    4930511A05Rik antibody; 4933415P08Rik antibody; E3 ubiquitin protein ligase NRDP1 antibody; E3 ubiquitin-protein ligase NRDP1 antibody; Fetal Liver RING finger protein antibody; FLRF antibody; MGC45228 antibody; Neuregulin receptor degradation protein 1 antibody; NRDP1 antibody; RING finger protein 41 antibody; rnf41 antibody; RNF41_HUMAN antibody; SBBI03 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase NRDP1 protein (1-317AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control.
  • 基因功能参考文献：
    1. Data (including data from studies using knockout and transgenic mice/cells) suggest that CLEC16A, NRDP1, and USP8 form tripartite complex; CLEC16A-NRDP1-USP8 complex appears to rely on ubiquitin signals to promote mitophagy and maintain mitochondrial function necessary for beta-cell function. (CLEC16A = C-type lectin domain family 16 member A; NRDP1 = ubiquitin-protein ligase NRDP1; USP8 = ubiquitin specific peptidase 8) PMID: 29180353
    2. Over-expression of miR-497 promotes the proliferation of glioma cells U87 by targeting Nrdp1. PMID: 28871945
    3. s conclude that the planar cell polarity (PCP) pathway contributes significantly to the motility and hence the invasiveness of glioblastoma multiforme (GBM) cells, and that Nrdp1 acts as a negative regulator of PCP signaling by inhibiting Dvl through a novel polyubiquitination mechanism. PMID: 28481871
    4. Data suggest that PHLPP1 plays an important role in assembly of kinetochores by counteracting RNF41-mediated SGT1 degradation. (PHLPP1 = PH domain and leucine rich repeat protein phosphatase 1; RNF41 = ring finger protein 41; SGT1 = suppressor of G2 allele of SKP1) PMID: 28696259
    5. Results show low expression level of NRDP1 in colorectal neoplasm independently of tumor stage. PMID: 27648936
    6. findings suggest that HBx promotes the progression of hepatocellular carcinoma by decreasing the stability of Nrdp1, which results in up-regulation of ErbB3 PMID: 26846102
    7. the association between RNF41 polymorphisms and congenital heart disease in the Chinese Mongolian population PMID: 27323192
    8. Nrdp1S is a tumour suppressor that which potentiates the Nrdp1-mediated ubiquitination and degradation of ErbB3. An Nrdp1S deficiency may also be an important factor in the loss of Nrdp1. PMID: 26612725
    9. HPV 16 E2 can modulate ErbB-3 by interacting with Nrdp-1, which is involved in the regulation of this receptor, via ubiquitination and degradation. PMID: 26963794
    10. The results of this study suggested that Nrdp1-mediated ErbB3 degradation suppresses glioma migration and invasion and that loss of Nrdp1 may amplify ErbB3 signaling to contribute to glioma migration and invasion. PMID: 26088461
    11. ABPN downregulates multiple components of the EGFR/ErbB3 signaling pathway through Nrdp1 activation. PMID: 26464195
    12. Nrdp1 may serve as a useful biomarker for the clinical outcome and efficacy of adjuvant anthracyclines-based chemotherapy in breast cancer. PMID: 25519010
    13. Lower expression of Nrdp1 in human glioma contributes tumor progression by reducing apoptosis. PMID: 25355637
    14. Phosphorylation of RNF41 by Par-1b regulates basolateral membrane targeting of laminin-111 receptors. PMID: 24259665
    15. Balanced reciprocal cross-regulation of RNF41 and USP8 determines whether receptors are sorted for lysosomal degradation or recycling, this way regulating basal cytokine receptor levels. PMID: 23750007
    16. Coiled-coil domain deletion abrogates Nrdp1 oligomerization and suppresses Nrdp1 but not ErbB3 ubiquitination and degradation. PMID: 24519943
    17. Data demonstrate that Nrdp1 preferentially associates with the nascent form of ErbB3 to accelerate its degradation, and that the two proteins colocalize at the endoplasmic reticulum. PMID: 21576364
    18. these data provide insights into understanding the potential role of Nrdp1 in cell growth, apoptosis and oxidative stress, and in the pathogenesis of Parkinson's disease. PMID: 21693106
    19. RNF41 interacts with JAK2-associated cytokine receptor complexes and modulates their cell surface exposure and signalling. PMID: 21378310
    20. Post-transcriptional mechanisms contribute to the suppression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors. PMID: 20628057
    21. Observations point to a model of CRPC development in which progression of PCa to castration resistance is associated with the inability of AR to transcriptionally regulate Nrdp1, and predict that inhibition of ErbB3 during AW may impair CRPC development. PMID: 20587519
    22. This study do not support the hypothesis of a major role for the Nrdp1 gene in PD development in the Chinese population. PMID: 19800834
    23. RNF41 mRNA measured by real time reverse-transcriptase polymerase chain reaction reaction quantifies heart allograft apoptosis in graft rejection. PMID: 20098290
    24. Nrdp1 can be important in the initiation of apoptosis by catalyzing ubiquitination and degradation of BRUCE. PMID: 14765125
    25. Results indicate that Nrdp1 is a specific target for the USP8 deubiquitinating enzyme and are consistent with a model where USP8 augments Nrdp1 activity by mediating its stabilization PMID: 15314180
    26. The USP8 recognition domain of NRDP1 has a novel protein fold that interacts with a conserved peptide loop of the rhodanese domain. PMID: 17035239
    27. Neuregulin 1-induced protein stability cascade involving USP8 and Nrdp1 mediates the down-regulation of ErbB3 PMID: 17210635

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  • 组织特异性：
    Detected in ovary, testis and prostate.
  • 数据库链接：

    HGNC: 18401

    KEGG: hsa:10193

    STRING: 9606.ENSP00000342755

    UniGene: Hs.524502