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RPA3 Antibody

  • 货号：
    CSB-PA16239A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA16239A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RPA3 Polyclonal antibody
  • Uniprot No.：
    P35244
  • 基因名：
  • 别名：
    p14 antibody; REPA 3 antibody; REPA3 antibody; Replication factor A protein 3 antibody; Replication protein A 14 kDa subunit antibody; Replication protein A3 14kD antibody; Replication protein A3 14kDa antibody; Replication protein A3 antibody; RF A antibody; RF A protein 3 antibody; RF-A protein 3 antibody; RFA protein 3 antibody; RFA3_HUMAN antibody; RP A antibody; RP A p14 antibody; RP-A p14 antibody; RPA 14 antibody; RPA 3 antibody; RPA p14 antibody; rpa3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Replication protein A 14 kDa subunit protein (1-119AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RPA3 Antibody (CSB-PA16239A0Rb)，的标记方式是Non-conjugated。对于RPA3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA16239B0Rb RPA3 Antibody, HRP conjugated ELISA
    FITC CSB-PA16239C0Rb RPA3 Antibody, FITC conjugated
    Biotin CSB-PA16239D0Rb RPA3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a maste...显示更多
  • 基因功能参考文献：
    1. RPA3 is a potential marker of prognosis, radioresistance and survival in nasopharyngeal carcinoma. PMID: 28557284
    2. Elevated expression of RPA3 promotes tumor progression in hepatocellular carcinoma cells. PMID: 28683444
    3. Up-regulation of RPA3 is involved in gastric cancer tumorigenesis and is associated with poorer patient survival. PMID: 28766245
    4. The allele "T" of rs6947203 in the RPA3 gene acts as a protective allele in glioma. PMID: 23573956
    5. RPA3 interacts directly with ssDNA on the 3'-side on a 31 nt ssDNA. PMID: 19010961

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 10291

    OMIM: 179837

    KEGG: hsa:6119

    STRING: 9606.ENSP00000223129

    UniGene: Hs.487540