RPA4 Antibody
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货号:CSB-PA020092GA01HU
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规格:¥3,900
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其他:
产品详情
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Uniprot No.:Q13156
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基因名:
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别名:HSU24186 antibody; MGC120333 antibody; MGC120334 antibody; p30 antibody; Replication factor A protein 4 antibody; Replication protein A 30 kDa subunit antibody; RF A antibody; RF-A protein 4 antibody; RFA antibody; RFA4_HUMAN antibody; RP A antibody; RP-A p30 antibody; RPA antibody; RPA4 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Human RPA4
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免疫原种属:Homo sapiens (Human)
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抗体亚型:IgG
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纯化方式:Antigen Affinity purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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产品提供形式:Liquid
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应用范围:ELISA,WB
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Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
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基因功能参考文献:
- Findings provide the first direct evidence for the function of alternative form of RPA in human DNA metabolism and support a model for aRPA functioning in chromosome maintenance functions in nonproliferating cells. PMID: 19996105
- Results suggest that RPA4 cannot support cell proliferation but can support processes that maintain the genomic integrity of the cell. PMID: 19942684
- Hyperphosphorylated replication protein A is preferentially localized to double-stranded break repair and the DNA damage checkpoint complexes in response to DNA damage. PMID: 15929725
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亚细胞定位:Nucleus. Note=Localizes to DNA repair foci after DNA damage.
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蛋白家族:Replication factor A protein 2 family
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组织特异性:Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels.
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数据库链接:
HGNC: 30305
OMIM: 300767
KEGG: hsa:29935
STRING: 9606.ENSP00000362131
UniGene: Hs.659349
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