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RPAIN Antibody

  • 货号：
    CSB-PA020093GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q86UA6
  • 基因名：
    RPAIN
  • 别名：
    2400006N03Rik antibody; DN-393H17.1 antibody; FLJ25625 antibody; FLJ30490 antibody; FLJ42429 antibody; HRIP antibody; MGC4189 antibody; Nuclear transporter antibody; RAP interaction protein antibody; RIP antibody; RIP_HUMAN antibody; RP23 83I13.5 antibody; RPA interacting protein antibody; RPA-interacting protein antibody; Rpain antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human RPAIN
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.
  • 基因功能参考文献：
    1. Suggest that increased RPAIN levels may contribute to the development of preeclampsia through regulating trophoblast invasion and apoptosis via C1q. PMID: 28032589
    2. hRIPalpha is involved in cell proliferation through regulation of RPA transport PMID: 23010595
    3. The results show that DDX3, eIF5A, and hRIP enhance HIV-1 internal ribosomal entry site-mediated translation. PMID: 21360055
    4. hRIPbeta localises to the PML nuclear body and transports replication protein A (PML) into the PML nuclear body and releases RPA upon UV irradiation. PMID: 16135809
  • 亚细胞定位：
    [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Nucleus, PML body.
  • 组织特异性：
    Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen.
  • 数据库链接：

    HGNC: 28641

    OMIM: 617299

    KEGG: hsa:84268

    STRING: 9606.ENSP00000385814

    UniGene: Hs.462086