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RPS19BP1 Antibody

  • 货号：
    CSB-PA160838
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using RPS19BP1 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RPS19BP1 Polyclonal antibody
  • Uniprot No.：
    Q86WX3
  • 基因名：
    RPS19BP1
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human RPS19BP1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.
  • 基因功能参考文献：
    1. AROS is a significant biomarker for tumor aggressiveness in non-cirrhotic hepatocellular carcinoma. PMID: 26339164
    2. In vitro SIRT1 activity assays disclose AROS as an inhibitor of SIRT1. PMID: 24681097
    3. study demonstrated a cancer-specific role for AROS in the regulation of survival in a panel of human cell lines; data suggest that AROS, as well as SIRT1, promotes survival in cancer cells while being redundant for viability in non-cancer cells PMID: 24258275
    4. This study analyses Sirt1 modulation by several putative Sirt1 regulators, showing that the regulator protein AROS has an unusual conformation and that the Sirt1 catalytic domain is sufficient for modulation by resveratrol. PMID: 23548308
    5. we found that the SIRT1 modulators AROS and DBC1 have an impact on hsp70 transcription, HSF1 acetylation status, and HSF1 recruitment to the hsp70 promoter. PMID: 23349863
    6. Active regulator of SIRT1 (AROS) is the first direct SIRT1 regulator to be identified that modulates p53-mediated growth regulation. PMID: 17964266

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  • 亚细胞定位：
    Nucleus, nucleolus.
  • 蛋白家族：
    AROS family
  • 组织特异性：
    Widely expressed (at protein level).
  • 数据库链接：

    HGNC: 28749

    OMIM: 610225

    KEGG: hsa:91582

    STRING: 9606.ENSP00000333948

    UniGene: Hs.526933