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RPS6KA4 Antibody

  • 货号：
    CSB-PA020467LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: U251 whole cell lysate, Mouse kidney tissue
      All lanes: RPS6KA4 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 86, 85 kDa
      Observed band size: 86 kDa
    • Immunofluorescent analysis of Hela cells using CSB-PA020467LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA020467LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RPS6KA4 Polyclonal antibody
  • Uniprot No.：
    O75676
  • 基因名：
  • 别名：
    90 kDa ribosomal protein S6 kinase 4 antibody; EC 2.7.11.1 antibody; KS6A4_HUMAN antibody; Mitogen and stress activated protein kinase 2 antibody; Nuclear mitogen and stress activated protein kinase 2 antibody; Nuclear mitogen- and stress-activated protein kinase 2 antibody; Ribosomal protein kinase B antibody; Ribosomal protein S6 kinase 90kD polypeptide 4 antibody; Ribosomal protein S6 kinase 90kDa polypeptide 4 antibody; Ribosomal protein S6 kinase alpha 4 antibody; Ribosomal protein S6 kinase alpha-4 antibody; RPS6KA4 antibody; RSKB antibody; S6K-alpha-4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Ribosomal protein S6 kinase alpha-4 protein (237-393AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RPS6KA4 Antibody (CSB-PA020467LA01HU)，的标记方式是Non-conjugated。对于RPS6KA4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA020467LB01HU RPS6KA4 Antibody, HRP conjugated ELISA
    FITC CSB-PA020467LC01HU RPS6KA4 Antibody, FITC conjugated
    Biotin CSB-PA020467LD01HU RPS6KA4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
  • 基因功能参考文献：
    1. Two novel DMRs, located in RPS6KA4/MIR1237 and the AURKC promoter, were found to be hypermethylated in WT PMID: 28930610
    2. KSHV activates the MSK1/2-CREB1 pathway during primary infection and that it depends on this pathway for viral lytic replication. I PMID: 26109721
    3. Data suggest that MSK1 and MSK2 are the major CREB kinases in fibroblast-like synoviocytes from rheumatoid arthritis patients stimulated with lysophosphatidic acid and that phosphorylation of CREB1 at Ser-133 plays a significant role in IL-8 production. PMID: 24792438
    4. MSK1 and MSK2 are required for maximal TFF 1 induction. PMID: 23675462
    5. MSK2 functions as an adaptor in mediating PKR activation, apparently independent of its catalytic activity. PMID: 21385567
    6. MSK1 and MSK2 are differentially regulated by CK2 during the UV response and that MSK2 is the major protein kinase responsible for the UV-induced phosphorylation of p65 at Ser(276) that positively regulates NF-kappaB activity in MDA-MB-231 cells PMID: 19933278
    7. Dimethylfumarate specifically inhibits MSK1 and 2 activations and subsequently inhibits NF-kappaB-induced gene-transcriptions, which are believed to be important in the pathogenesis of psoriasis PMID: 17495961

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
  • 数据库链接：

    HGNC: 10433

    OMIM: 603606

    KEGG: hsa:8986

    STRING: 9606.ENSP00000333896

    UniGene: Hs.105584