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  4. RRBP1 Antibody

RRBP1 Antibody

  • 货号：
    CSB-PA083779
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA083779(RRBP1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA083779(RRBP1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: K562 cells, Primary antibody: CSB-PA083779(RRBP1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q9P2E9
  • 基因名：
  • 别名：
    180 kDa ribosome receptor homolog antibody; DKFZp586A1420 antibody; ES/130 antibody; ES/130 related protein antibody; ES/130-related protein antibody; ES130 antibody; FLJ36146 antibody; hES antibody; KIAA1398 antibody; MGC157720 antibody; MGC157721 antibody; Ribosome binding protein 1 antibody; Ribosome binding protein 1 homolog 180kDa antibody; Ribosome binding protein 1 homolog antibody; Ribosome receptor protein antibody; Ribosome-binding protein 1 antibody; RRBP 1 antibody; Rrbp1 antibody; RRBP1_HUMAN antibody; RRP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human RRBP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.
  • 基因功能参考文献：
    1. High RRBP1 expression facilitates colorectal cancer progression and predicts an unfavourable post-operative prognosis. PMID: 26196185
    2. Data indicate that p180 is required for the efficient targeting of placental alkaline phosphatase (ALPP) mRNA to the endoplasmic reticulum (ER). PMID: 24019514
    3. RRBP1 could alleviate ER stress and help cancer cell survive PMID: 23318453
    4. p180 is concentrated in ER sheets by interacting with polysomes and may play a role in ER morphology. PMID: 21111237
    5. p180 promotes the ribosome-independent localization of a subset of mRNA to the endoplasmic reticulum. PMID: 22679391
    6. A novel function of p180-abundant endoplasmic reticulum on the trans-Golgi network expansion, both of which are highly developed in various professional secretory cells. PMID: 19932094
    7. p180 plays crucial roles in enhancing collagen biosynthesis at the entry site of the secretory compartments by a novel mechanism that mainly involves facilitating ribosome association on the ER. PMID: 20647306
    8. Results identify the ribosome receptor, p180, as a binding partner of the kinesin heavy chain isoform KIF5B. PMID: 15184079
    9. These data suggest that p180 mediates interactions between the endoplasmic reticulum and microtubules mainly through the novel microtubule-binding and -bundling domain MTB-1. PMID: 17634287
    10. over-expression of p180R failed to increase secretory pathway proteins calnexin, SEC61beta, and calreticulin, or ribosome biogenesis PMID: 18083570
    11. results obtained demonstrate that p180 is both necessary & sufficient to induce a secretory phenotype in mammalian cells; findings support a central role for p180 in the terminal differentiation of secretory cells & tissues PMID: 19037105
    12. the discovery overexpression of GPD1 and RRBP1 proteins and lack of expression for HNRNPH1 and SERPINB6 proteins which are new candidate biomarkers of colon cancer. PMID: 19425502

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type III membrane protein.
  • 数据库链接：

    HGNC: 10448

    OMIM: 601418

    KEGG: hsa:6238

    STRING: 9606.ENSP00000354045

    UniGene: Hs.472213