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RSU1 Antibody

  • 货号：
    CSB-PA040281
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q15404
  • 基因名：
    RSU1
  • 别名：
    FLJ31034 antibody; Ras suppressor protein 1 antibody; Ras suppressor protein 1 isoform 1 antibody; RSP 1 antibody; RSP-1 antibody; RSP1 antibody; RSU 1 antibody; Rsu-1 antibody; RSU1 antibody; RSU1 protein antibody; RSU1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Rsu-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.
  • 基因功能参考文献：
    1. our results indicate the important role of RSU-1 in BC metastasis and set the foundations for its validation as potential BC metastasis marker. PMID: 28423706
    2. Ras suppressor protein 1 was confirmed to be directly targeted by miR-409-5p in breast cancer cells. Small interfering RNA-mediated Ras suppressor protein 1 inhibition reversely promoted cancer proliferation and migration in miR-409-5p-downregualted breast cancer cells. MiR-409-5p is downregulated in breast cancer and its inhibition has anti-cancer effect on breast cancer development both in vitro and in vivo. PMID: 28459205
    3. Rsu1 is required for EGF-induced activation of the p38 map kinase signaling PMID: 25482629
    4. integrin/Rsu1/Rac1/actin signaling has a conserved role in modulating reward-related phenotypes, including ethanol consumption, across phyla PMID: 26170296
    5. Upregulation of RSU1 is associated with metastatic breast cancer. PMID: 25647720
    6. results showed that RSU-1 expression is elevated in HepG2 cells both at the mRNA and protein level PMID: 25750304
    7. alternative splicing of exon 8 of the RSU-1 RNA to produce the exon-deleted form constitutes a mechanism for reduction or loss of functional Rsu-1. The exon-deleted form was not found in normal tissue. PMID: 12510772
    8. Rsu-1 links the Ras pathway with the IPP (integrin-linked kinase {ILK}, PINCH-1/LIMS1, parvin) complex and the perturbations of cell attachment-dependent signaling that occur in the malignant process PMID: 18436335

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  • 数据库链接：

    HGNC: 10464

    OMIM: 179555

    KEGG: hsa:6251

    STRING: 9606.ENSP00000339521

    UniGene: Hs.524161