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RUSC1 Antibody

  • 货号：
    CSB-PA020596GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BVN2
  • 基因名：
    RUSC1
  • 别名：
    RUSC1 antibody; NESCARUN and SH3 domain-containing protein 1 antibody; New molecule containing SH3 at the carboxy-terminus antibody; Nesca antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RUSC1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. Signaling adapter which plays a role in neuronal differentiation. Involved in regulation of NGF-dependent neurite outgrowth. May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.
  • 基因功能参考文献：
    1. RUN domain of NESCA can bind H-Ras, a downstream signaling molecule of TrkA, with high affinity. Moreover, NESCA RUN can directly interact with TrkA. PMID: 22821014
    2. Nesca functions as an adapter involved in neuronal vesicular transport PMID: 22404429
    3. Data show that NESCA and NEMO interact by their N-terminal region, that NESCA directly associates with TRAF6, which in turn catalyzes NESCA polyubiquitination, and that NESCA overexpression strongly inhibits TRAF6-mediated polyubiquitination of NEMO. PMID: 19365808
  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Early endosome. Cell junction, synapse, postsynaptic density. Golgi apparatus.
  • 组织特异性：
    Predominantly expressed in brain.
  • 数据库链接：

    HGNC: 17153

    OMIM: 617318

    KEGG: hsa:23623

    STRING: 9606.ENSP00000357336

    UniGene: Hs.226499