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Reg3b Antibody

  • 货号：
    CSB-PA326510LA01RA
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Rattus norvegicus (Rat) Reg3b Polyclonal antibody
  • Uniprot No.：
    P25031
  • 基因名：
    Reg3b
  • 别名：
    Reg3b antibody; Pap antibody; Pap1 antibody; Reg2 antibody; Regenerating islet-derived protein 3-beta antibody; REG-3-beta antibody; Pancreatitis-associated protein 1 antibody; Peptide 23 antibody; REG-2 antibody; Regenerating islet-derived protein III-beta antibody; Reg III-beta) [Cleaved into: Regenerating islet-derived protein 3-beta 16.5 kDa form; Regenerating islet-derived protein 3-beta 15 kDa form] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Rat
  • 免疫原：
    Recombinant Rat Regenerating islet-derived protein 3-beta protein (27-175AA)
  • 免疫原种属：
    Rattus norvegicus (Rat)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Reg3b Antibody (CSB-PA326510LA01RA)，的标记方式是Non-conjugated。对于Reg3b Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA326510LB01RA Reg3b Antibody, HRP conjugated ELISA
    FITC CSB-PA326510LC01RA Reg3b Antibody, FITC conjugated
    Biotin CSB-PA326510LD01RA Reg3b Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Bactericidal C-type lectin which acts against several intestinal Gram-positive bacteria and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues.
  • 基因功能参考文献：
    1. These results demonstrate a direct effect of INGAP-PP on the liver acting through P-Akt signaling pathway. INGAP-PP enhances liver glucose metabolism and deposit and reduces its production/output, thereby contributing to maintain normal glucose homeostasis. PMID: 29305881
    2. Reg3beta-dependent accumulation of macrophages in the ischemic heart has a role in myocardial healing PMID: 25751817
    3. Alox15 mRNA levels were 4 times higher in iron-deficient than in iron-adequate pancreas and that Reg1a, Reg3a, and Reg3b mRNA levels were 17-36 times higher in iron-overloaded pancreas. PMID: 24465846
    4. Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats PMID: 24587207
    5. Findings suggest that islet neogenesis-associated protein (INGAP) exerts a positive modulatory effect on beta-cell mass and its secretory function in fetal and neonatal rats, thus becoming a new component in the multifactorial regulation of such processes. PMID: 23303201
    6. After duodenal-jejunal bypass, the level of Reg3alpha and -3beta were not changed in bypassed duodenum in morbidly obese Zucker fatty rats. PMID: 23370676
    7. In older animals, there is depressed PAP expression related to a blunted inflammatory response in acute pancreatitis which is associated with worsened bacterial infiltration and higher C-reactive protein level PMID: 22807607
    8. PAP-I and PAP-III induction in non-gamma- aminobutyric acid (GABA)ergic neurons might protect these neurons against damage following seizure. PMID: 21093549
    9. Letter: aggregation status of PAP1 and PAP2 could change their role in regulating the inflammation in acute pancreatitis. PMID: 21926556
    10. Pancreatitis-associated protein I could play a role similar to that of IL-10 in epithelial cells. PMID: 16517747
    11. Thus, PAP family members may have an anti-inflammatory role, and this may contribute to the protection of injured neurons. PMID: 19351265
    12. There is a tight spatial and temporal association between pre-inflammatory changes or inflammation and PAP-expression PMID: 15100001
    13. Sepsis resulted in an up-regulation of PAP-1 gene expression and increase in its protein level in pancreas. The functional role of PAP-1 production in sepsis needs further investigation. PMID: 15211109
    14. These results suggest that Reg family members would be new mediators among injured neurons and glial cells, and may play pivotal roles during nerve regeneration. PMID: 15896308
    15. pancreatitis-associated protein-I is implicated in the abnormal sensation in cystitis. PMID: 18295254
    16. The Reg/PAP family, which was found to show dramatically increasing gene expressions by DNA microarray analysis, was suspected to play an important role in myocarditis. PMID: 18774541
    17. Results indicated that the mechanism of PAP1 action involves the activation of the mitogen-activated protein kinase superfamily. PMID: 19434369
    18. PAP1 mrna expression was higher in vena cava versus thoracic aorta. PMID: 19571575
    19. Results indicate that PAP-1 may be a defensive gene for oxidative stress-induced cell death of pancreatic acinar cells. PMID: 19723102

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  • 相关疾病：
    Overexpressed during the acute phase of pancreatitis.
  • 亚细胞定位：
    Secreted. Note=Found in the apical region of pancreatic acinar cells.
  • 组织特异性：
    Constitutively expressed in intestine.
  • 数据库链接：

    KEGG: rno:24618

    STRING: 10116.ENSRNOP00000008212

    UniGene: Rn.9727