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S100A16 Antibody

  • 货号：
    CSB-PA853418LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA853418LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA853418LA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA853418LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) S100A16 Polyclonal antibody
  • Uniprot No.：
    Q96FQ6
  • 基因名：
    S100A16
  • 别名：
    2300002L21Rik antibody; AAG13 antibody; Aging associated gene 13 protein antibody; Aging associated protein 13 antibody; Aging-associated gene 13 protein antibody; AI325039 antibody; AI663996 antibody; DT1P1A7 antibody; MGC17528 antibody; Protein S100 A16 antibody; Protein S100-A16 antibody; Protein S100-F antibody; Protein S100F antibody; S100 calcium binding protein A16 antibody; S100 calcium-binding protein A16 antibody; S100A16 antibody; S100F antibody; S10AG_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein S100-A16 protein (1-103AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，S100A16 Antibody (CSB-PA853418LA01HU)，的标记方式是Non-conjugated。对于S100A16 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA853418LB01HU S100A16 Antibody, HRP conjugated ELISA
    FITC CSB-PA853418LC01HU S100A16 Antibody, FITC conjugated
    Biotin CSB-PA853418LD01HU S100A16 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium-binding protein. Binds one calcium ion per monomer. Can promote differentiation of adipocytes (in vitro). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake.
  • 基因功能参考文献：
    1. Low S100A16 expression is associated with colorectal cancer. PMID: 28876468
    2. Data show that overexpression of S100 calcium binding protein A16 protein (S100A16) activated AKT protein and ERK signaling pathways. PMID: 27240591
    3. These results indicate that S100 calcium binding protein A16 is a differentiation promoting protein and might function as a tumor suppressor in oral squamous cell carcinoma. PMID: 26353754
    4. S100A16 had a potential function to regulate some embryonic transcription factors to promote epithelial-mensenchymal transition in breast cancer cells which may be an important target site for the therapy of breast cancer. PMID: 25287362
    5. The presence of hydrophobic interactions stronger than for other S100 proteins, present in the closed form of S100A16 between the third and fourth helices, likely make the closed structure of the second EF-hand particularly stable. PMID: 21046186

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  • 亚细胞定位：
    Nucleus, nucleolus. Cytoplasm. Note=Primarily nucleolar. A high intracellular calcium level induces nucleolar exit and nucleocytoplasmic transport, whereas a low intracellular calcium level leads to nuclear translocation and accumulation within specific region of nucleoli (PubMed:17030513).
  • 蛋白家族：
    S-100 family
  • 组织特异性：
    Ubiquitous. Highly expressed in esophagus, adipose tissues and colon. Expressed at lower level in lung, brain, pancreas and skeletal muscle. Expression is up-regulated in tumors of bladder, lung, thyroid gland, pancreas and ovary. Expressed in astrocytes.
  • 数据库链接：

    HGNC: 20441

    OMIM: 617437

    KEGG: hsa:140576

    STRING: 9606.ENSP00000357692

    UniGene: Hs.515714