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SAE1 Antibody

  • 货号：
    CSB-PA794022
  • 规格：
    ￥2024
  • 图片：
    • Immunofluorescence analysis of HuvEc cells, using AOS1 antibody.
    • Western blot analysis of extracts from 293 cells, using AOS1 antibody.
    • Western blot analysis of extracts from Colo cells, HepG2 cells and 293 cells using AOS1 antibody. The lane on the left is treated with synthesized peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SAE1 Polyclonal antibody
  • Uniprot No.：
    Q9UBE0
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Internal of Human AOS1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
  • 基因功能参考文献：
    1. the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype. PMID: 26403403
    2. as it has been shown by flow cytometry analysis, specific knockdown of SAE1 slowed down the cell population at G0/G1 phase and induced apoptosis of RKO cells. PMID: 25842831
    3. SUMO-1 controls the protein stability and the biological function of phosducin. PMID: 16421094
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Ubiquitin-activating E1 family
  • 组织特异性：
    Expression level increases during S phase and drops in G2 phase (at protein level).
  • 数据库链接：

    HGNC: 30660

    OMIM: 613294

    KEGG: hsa:10055

    STRING: 9606.ENSP00000270225

    UniGene: Hs.515500