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SAMD8 Antibody

  • 货号：
    CSB-PA822254LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA822254LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA822254LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SAMD8 Polyclonal antibody
  • Uniprot No.：
    Q96LT4
  • 基因名：
    SAMD8
  • 别名：
    SAMD8; Sphingomyelin synthase-related protein 1; SMSr; Ceramide phosphoethanolamine synthase; CPE synthase; Sterile alpha motif domain-containing protein 8; SAM domain-containing protein 8
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Sphingomyelin synthase-related protein 1 protein (1-152AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SAMD8 Antibody (CSB-PA822254LA01HU)，的标记方式是Non-conjugated。对于SAMD8 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA822254LB01HU SAMD8 Antibody, HRP conjugated ELISA
    FITC CSB-PA822254LC01HU SAMD8 Antibody, FITC conjugated
    Biotin CSB-PA822254LD01HU SAMD8 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.
  • 基因功能参考文献：
    1. findings underscore a role of SMSr as negative regulator of ceramide-induced cell death PMID: 28659495
    2. These results indicate a primary role of SMSr in monitoring endoplasmic reticulum ceramide levels. PMID: 24259670
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sphingomyelin synthase family
  • 数据库链接：

    HGNC: 26320

    OMIM: 611575

    KEGG: hsa:142891

    STRING: 9606.ENSP00000438042

    UniGene: Hs.744986