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SAMM50 Antibody

  • 货号：
    CSB-PA896898ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SAMM50 antibody at 0.98µg/ml
      Lane 1: Mouse gonadal tissue
      Lane 2: A375 whole cell lysate
      Lane 3: A431 whole cell lysate
      Lane 4: 293T whole cell lysate
      Lane 5: Hela whole cell lysate
      Lane 6: A549 whole cell lysate
      Lane 7: HepG2 whole cell lysate
      Lane 8: U251 whole cell lysate
      Lane 9: LO2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 52 kDa
      Observed band size: 52 kDa
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA896898ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA896898ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SAMM50 Polyclonal antibody
  • Uniprot No.：
    Q9Y512
  • 基因名：
    SAMM50
  • 别名：
    CGI 51 antibody; CGI-51 antibody; FLJ35825 antibody; FLJ42905 antibody; FLJ99036 antibody; OMP85 antibody; SAM50 antibody; SAM50_HUMAN antibody; Samm50 antibody; sorting and assembly machinery 50kDa antibody; sorting and assembly machinery component 50 homolog (S. cerevisiae) antibody; Sorting and assembly machinery component 50 homolog antibody; sorting and assembly machinery component 50, S. cerevisiae, homolog of antibody; TOB55 antibody; Transformation-related gene 3 protein antibody; TRG-3 antibody; YNL026W antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Sorting and assembly machinery component 50 homolog protein (1-220AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex.
  • 基因功能参考文献：
    1. The s results demonstrate that SNP in the SAMM50 gene is significantly associated with the presence and severity of NAFLD in a Korean populations. PMID: 29271184
    2. Findings suggest a significant association between variants in COL13A1, ADIPOQ, SAMM50, and PNPLA3, and risk of NAFLD/elevated transaminase levels in Mexican adults with an admixed ancestry. PMID: 29307798
    3. SAMM50 affects the Drp1-dependent mitochondrial morphology. PMID: 27059175
    4. downregulation of SAM50 in BCR-ABL-expressing, but not normal CD34(+) human hematopoietic stem and progenitor cells (HSPCs) caused a significant decrease in growth, colony formation, and replating capacity. PMID: 26855047
    5. the integrity of MICOS and its efficient interaction with Sam50 are indispensable for cristae organization, which is relevant to mitochondrial function. PMID: 26530328
    6. Polymorphisms in the SAMM50 and PARVB genes in addition to those in the PNPLA3 gene were observed to be associated with the development and progression of NAFLD. PMID: 23535911
    7. The study describes a novel role of SAM50 in maintaining the mitochondrial shape and the morphology of cristae. PMID: 22252321

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  • 亚细胞定位：
    Mitochondrion outer membrane; Multi-pass membrane protein. Cytoplasm. Mitochondrion.
  • 蛋白家族：
    SAM50/omp85 family
  • 数据库链接：

    HGNC: 24276

    OMIM: 612058

    KEGG: hsa:25813

    STRING: 9606.ENSP00000345445

    UniGene: Hs.505824