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SAR1A Antibody

  • 货号：
    CSB-PA873630ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SAR1A antibody at 4.57μg/ml
      Lane 1: Mouse lung tissue
      Lane 2: NIH/3T3 whole cell lysate
      Lane 3: A431 whole cell lysate
      Lane 4: MCF-7 whole cell lysate
      Lane 5: Jurkat whole cell lysate
      Lane 6: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 23, 18 kDa
      Observed band size: 23 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA873630ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SAR1A Polyclonal antibody
  • Uniprot No.：
    Q9NR31
  • 基因名：
  • 别名：
    COPII associated small GTPase antibody; COPII-associated small GTPase antibody; GTP binding protein SAR1a antibody; GTP-binding protein SAR1a antibody; Masra 2 antibody; Masra2 antibody; SAR 1 antibody; SAR1 gene homolog A antibody; SAR1 homolog A (S. cerevisiae) antibody; SAR1A antibody; SAR1a gene homolog (S cerevisiae) 1 antibody; SAR1a gene homolog 1 (S cerevisiae) antibody; SAR1a gene homolog 1 antibody; SAR1A_HUMAN antibody; SARA 1 antibody; Sara antibody; SARA1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human GTP-binding protein SAR1a protein (1-198AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).
  • 基因功能参考文献：
    1. Study data suggest that SAR1A and SAR1B are the critical regulators of trafficking of Nav1.5. Moreover, SAR1A and SAR1B interact with MOG1, and are required for MOG1-mediated cell surface expression and function of Nav1.5. PMID: 30251687
    2. Study shows that the bona fide nonglycoprotein Nox5, a transmembrane superoxide-producing NADPH oxidase, is transported to the cell surface in a manner resistant to co-expression of Sar1 (H79G), a GTP-fixed mutant of the small GTPase Sar1, which blocks COPII vesicle fission from the endoplasmic reticulum. PMID: 29718541
    3. No associations were observed between any of the secretion associated Ras related GTPase 1A (SAR1a) promoter variants and baseline fetal hemoglobin HbF among sickle cell disease (SCD) patients. PMID: 28499394
    4. Sar1 is a novel regulator of endoplasmic reticulum-mitochondrial contact sites in the metazoans. PMID: 27101143
    5. SAR1A gene silencing in hepatocytes mimics the effect of ethanol: dedimerization of giantin, arresting PDIA3 in the endoplasmic reticulum (ER) and large-scale alterations in Golgi architecture. PMID: 26607390
    6. Data indicate that hydroxyurea (HU) induces SAR1 protein expression, which in turn activates gamma-globin expression, predominantly through the Gialpha/JNK/Jun pathway. PMID: 24914133
    7. although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo. PMID: 24338480
    8. Sar1 mutant proteins added to metaphase-arrested Xenopus laevis egg extracts cause dramatic effects on membrane organization. PMID: 22605651
    9. the behavior of the human of Sar1A and Sar1B, a key component of the COPII family of vesicle coat proteins, was examined. PMID: 22974979
    10. Sedlin bound and promoted efficient cycling of Sar1, a guanosine triphosphatase that can constrict membranes, and thus allowed nascent carriers to grow and incorporate procollagen prefibrils. PMID: 23019651
    11. lipid-directed and tether-assisted Sar1 organization controls membrane constriction to regulate ER export. PMID: 20624903
    12. the intracellular trafficking of hCaR from the endoplasmic reticulum is Sar1-dependent via coat protein complex-II vesicles. PMID: 20457124
    13. The Sec31 fragment stimulates GAP activity of Sec23/24, and a convergence of Sec31 and Sec23 residues at the Sar1 GTPase active site explains how GTP hydrolysis is triggered leading to COPII coat disassembly. PMID: 17981133
    14. Sar 1 H79G mutants efficiently blocked the plasma membrane trafficking of the Kir3.1/Kir3.4 complex however they did not block the Gbeta1gamma2/Kir3.1 interaction. PMID: 19135528
    15. Kir6.2 contains a di-acidic endoplasmic reticulum exit signal, which promotes endoplasmic reticulum exit via a process that requires Sar1. PMID: 19357197

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  • 亚细胞定位：
    Endoplasmic reticulum. Golgi apparatus.
  • 蛋白家族：
    Small GTPase superfamily, SAR1 family
  • 数据库链接：

    HGNC: 10534

    OMIM: 607691

    KEGG: hsa:56681

    STRING: 9606.ENSP00000362335

    UniGene: Hs.499960