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SAR1B Antibody

  • 货号：
    CSB-PA296125
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from LOVO cells and RAW264.7 cells, using SAR1B antibody.
    • Immunohistochemistry analysis of paraffin-embedded human placenta tissue using SAR1B antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SAR1B Polyclonal antibody
  • Uniprot No.：
    Q9Y6B6
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human SAR1B.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis.
  • 基因功能参考文献：
    1. Study data suggest that SAR1A and SAR1B are the critical regulators of trafficking of Nav1.5. Moreover, SAR1A and SAR1B interact with MOG1, and are required for MOG1-mediated cell surface expression and function of Nav1.5. PMID: 30251687
    2. Targeted next generation DNA sequencing revealed several rare heterozygous missense variants in both MTTP and APOB genes known or predicted to be deleterious, in addition to a novel heterozygous missense variant in SAR1B, which encodes the gene causing chylomicron retention disease PMID: 29540175
    3. Report compensatory Sar1a elevation after Sar1b gene deletion in Caco-2/15 cells prevents chylomicron collapse. PMID: 28982670
    4. SAR1B polymorphisms were associated with Alzheimer's disease (AD) risk; results were not significant after correction for multiple tests. Simultaneous screening using SAR1B rs11948613 and ApoE epsilon4 status offered a better sensitivity for AD screening. PMID: 25703997
    5. Our data also suggest that Sar1B overexpression contributes to regulation of CHOL transport and metabolism by facilitating rapid uptake and transport of CHOL. PMID: 25826777
    6. although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo. PMID: 24338480
    7. the behavior of the human of Sar1A and Sar1B, a key component of the COPII family of vesicle coat proteins, was examined. PMID: 22974979
    8. Sar1b expression may promote intestinal lipid transport with the involvement of the coat protein complex II network and the processing of SREBP-1c. PMID: 21836065
    9. Variable phenotypic expression of chylomicron retention disease in a kindred carrying a mutation of the Sara2 gene. PMID: 19846172
    10. identify eight mutations in SARA2 that are associated with three severe disorders of fat malabsorption PMID: 12692552
    11. Sara2 is an important gene in processes involving erythroid cell proliferation and differentiation. PMID: 15943909
    12. Five mutations in the SAR1B gene causing Anderson disease. PMID: 17945526
    13. muscular as well as cardiac abnormalities that could be related to the reported expression of SARA2 in these tissues PMID: 18786134

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  • 相关疾病：
    Chylomicron retention disease (CMRD)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
  • 蛋白家族：
    Small GTPase superfamily, SAR1 family
  • 组织特异性：
    Expressed in many tissues including small intestine, liver, muscle and brain.
  • 数据库链接：

    HGNC: 10535

    OMIM: 246700

    KEGG: hsa:51128

    STRING: 9606.ENSP00000385432

    UniGene: Hs.432984