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SCAF8 Antibody

  • 货号：
    CSB-PA008259
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of JK cells using RBM16 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9UPN6
  • 基因名：
    SCAF8
  • 别名：
    SCAF8 antibody; CCAP7 antibody; KIAA1116 antibody; RBM16 antibody; SR-related and CTD-associated factor 8 antibody; CDC5L complex-associated protein 7 antibody; RNA-binding motif protein 16 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human RBM16.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation.
  • 基因功能参考文献：
    1. SCAF8-CNKSR3 variant rs955333 was not associated with diabetic kidney disease but showed association with diabetic retinopathy in Chinese type 2 diabetes patients PMID: 28401168
  • 亚细胞定位：
    Nucleus. Nucleus matrix.
  • 数据库链接：

    HGNC: 20959

    OMIM: 616024

    KEGG: hsa:22828

    STRING: 9606.ENSP00000356146

    UniGene: Hs.591329