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SCGN Antibody

  • 货号：
    CSB-PA020821GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O76038
  • 基因名：
    SCGN
  • 别名：
    Calbindin like antibody; CALBL antibody; DJ501N12.8 antibody; OTTHUMP00000016124 antibody; Scgn antibody; SECRET antibody; Secretagogin antibody; Secretagogin EF hand calcium binding protein antibody; SEGN antibody; SEGN_HUMAN antibody; Setagin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SCGN
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. the overexpression of SCGN in SW480 human colorectal cancer cells promoted cell apoptosis and inhibited cell migration and invasion. PMID: 29499408
    2. Glucose-dependent de-SUMOylation of tomosyn1 at K298 releases syntaxin1A and controls the amplification of exocytosis in concert with a recently-identified tomosyn1-interacting partner; the Ca(2+)-binding protein secretagogin, which dissociates from tomosyn1 in response to Ca(2+)-raising stimuli and is required for insulin granule trafficking and exocytosis downstream of Ca(2+) influx. PMID: 28325894
    3. secretagogin is a potential biomarker, reflecting stress and islet cell dysfunction in T2D patients PMID: 29702679
    4. Secretagogin-dependent MMP2 release from neurons regulates neuroblast migration. PMID: 28223495
    5. The low SCGN plasma levels in children with ASD probably indicate that SCGN might be implicated in the pathogenesis of autism. However, these data should be treated with caution until further investigations are performed using larger sample sizes to determine whether the decrease in plasma SCGN levels is a mere consequence of autism or it plays a pathogenic role in the disease. PMID: 28492151
    6. Therefore, and considering the desensitization of TRPV1s in diabetic pancreata, a TRPV1-to-secretagogin regulatory axis seems critical to maintain the structural integrity and signal competence of beta-cells. PMID: 28637794
    7. These results suggest SCGN is involved in the chemoresistance of small cell lung cancer under the regulation of miR-494 PMID: 25226615
    8. Scgn is a CaBP expressed in a subpopulation of nociceptive DRG neurons and their processes in the dorsal horn. PMID: 23102406
    9. While secretagogin mRNA was detected in both peripheral mononuclear cells and erythrocytes using reverse-transcription polymerase chain reaction, SCGN protein was only detected in erythrocytes. PMID: 22921511
    10. Data show that the density of secretagogin-positive neurons selectively decreases in the olfactory tract in Alzheimer's disease. PMID: 22474393
    11. Levels of secretagogin correlate with mortality and are useful as predictors of outcome in children with traumatic brain injury. PMID: 21976236
    12. Ddetection of novel calcium-binding protein secretagogin within subgroup of clear-cell renal cell carcinomas. Increased metastasis rates within secretagogin-positive subgroup of clear-cell renal cell carcinomas. PMID: 21288557
    13. Results emphasize the developmentally shared origins of neurons populating the extended amygdala, and suggest that secretagogin can be relevant to the generation of functional modalities in specific neuronal circuitries. PMID: 20529129
    14. Secretagogin might play a role in human non-functional pituitary adenomas. This novel finding may provide clues to clarify the basic molecular mechanisms of pituitary adenoma formation, and to identify new tumor-related markers. PMID: 15237930
    15. two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin PMID: 15766553
    16. We identified and characterized promoter activity of a human 1498 bp secretagogin sequence upstream the transcription start site. PMID: 17083620

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  • 亚细胞定位：
    Cytoplasm. Secreted. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
  • 组织特异性：
    Expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression is restric
  • 数据库链接：

    HGNC: 16941

    OMIM: 609202

    KEGG: hsa:10590

    STRING: 9606.ENSP00000367197

    UniGene: Hs.116428