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SCML2 Antibody

  • 货号：
    CSB-PA004749
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using SCML2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9UQR0
  • 基因名：
    SCML2
  • 别名：
    SCML2 antibody; SCML2_HUMAN antibody; sex comb on midleg like 2 (Drosophila) antibody; Sex comb on midleg like 2 antibody; Sex comb on midleg like protein 2 antibody; Sex comb on midleg, Drosophila, homolog-like 2 antibody; Sex comb on midleg-like protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human SCML2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development.
  • 基因功能参考文献：
    1. SCML2A, an SCML2 isoform tightly associated to chromatin, contributes to PRC1 localization and also directly enforces repression of certain Polycomb target genes. PMID: 24986859
    2. SCML2 directly interacts with USP7 and drives its localization. SCML2 connects USP7 to PRC1.4, allowing for the stabilization of BMI1, and USP7 is found on SCML2 and BMI1 target genes. PMID: 25605328
    3. Because PRC1 complexes localize to the promoters of a specific subset of developmental genes in vivo, the SLED domain of Scml2 may provide an important link connecting the PRC1 complexes to their target genes. PMID: 24727478
    4. 1.78-A crystal structure of the two MBT repeats of SCML2 show significant structural similarities to the Tudor, PWWP, and chromo domains, suggesting probable evolutionary relationships and functional similarities between the MBT repeats and these domains. PMID: 12952983
    5. The malignant brain tumor repeats of SCML2 preferentially bind histone peptides monomethylated at lysine residues. The crystal structure of the complex reveals that the modified amino acid binds to an aromatic rich pocket. PMID: 18706910

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    SCM family
  • 组织特异性：
    Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.
  • 数据库链接：

    HGNC: 10581

    OMIM: 300208

    KEGG: hsa:10389

    STRING: 9606.ENSP00000251900

    UniGene: Hs.495774