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SCYL1 Antibody

  • 货号：
    CSB-PA839356DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA839356DSR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SCYL1 Polyclonal antibody
  • Uniprot No.：
    Q96KG9
  • 基因名：
    SCYL1
  • 别名：
    Coated vesicle associated kinase of 90 kDa antibody; Coated vesicle-associated kinase of 90 kDa antibody; CVAK90 antibody; GKLP antibody; HT019 antibody; Likely ortholog of mouse N terminal kinase like protein antibody; MGC78454 antibody; N terminal kinase like antibody; N terminal kinase like protein antibody; N-terminal kinase-like protein antibody; NKTL antibody; NTKL antibody; NTKL_HUMAN antibody; NTKLBP1 antibody; P105 antibody; SCY L1 antibody; SCY1 like 1 antibody; SCY1 like 1 protein 1 antibody; SCY1-like protein 1 antibody; SCYL 1 antibody; Scyl1 antibody; SCYL1BP1 antibody; TAPK antibody; TEIF antibody; Telomerase regulation associated protein antibody; Telomerase regulation-associated protein antibody; Telomerase transcriptional element interacting factor antibody; Telomerase transcriptional element-interacting factor antibody; Teratoma associated tyrosine kinase antibody; Teratoma-associated tyrosine kinase antibody; TRAP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human N-terminal kinase-like protein (460-740AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro.; Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.
  • 基因功能参考文献：
    1. findings indicate that SCYL1 does not contribute to REST turnover and thus do not support a previous study suggesting a role for SCYL1 in mediating REST degradation PMID: 28570664
    2. Disruptive SCYL1 mutations underlie a syndrome characterized by recurrent episodes of liver failure, peripheral neuropathy, cerebellar atrophy, and ataxia. PMID: 26581903
    3. Data identified the large GTPase dynamin2 as an interacting protein of NTKL, which might be responsible for the phenotype alterations caused by NTKL overexpression, such as cytokinesis failure, increased cell motility and abnormal of cell division. PMID: 25575811
    4. Data reveal that Scyl1 is a key organizer of a subset of the COPI machinery. PMID: 24481816
    5. TEIF is a downstream effector in EGF/PI3K/Akt signaling. PMID: 24769208
    6. TEIF as a novel MSP58-interacting protein. PMID: 24361335
    7. suggested that the interaction of SCYL1BP1/Pirh2 could accelerate Pirh2 degradation through an ubiquitin-dependent pathway. SCYL1BP1 may function as an important tumor suppressor gene in HCC development PMID: 22570270
    8. TEIF protein and centrosome amplification is commonly found in colorectal tumors. The expression level of TEIF is related to tumor histological grade and malignant degree. PMID: 19958622
    9. Scyl1 interacts with 58K/formiminotransferase cyclodeaminase (FTCD) and golgin p115, and is required for the maintenance of Golgi morphology PMID: 20209057
    10. Scyl1 participates in the nuclear aminoacylation-dependent tRNA export pathway. PMID: 20505071
    11. SCYL1-BP1 can be ubiquitinated and degraded by Pirh2 but not by MDM2, which suggests that SCYL1-BP1 can be regulated by Pirh2. PMID: 20598683
    12. NTKL is involved in centrosome-related cellular functions PMID: 12036289
    13. Molecular cloning of telomerase transcriptional elements-interacting factor,(TEIF). TEIF may take part in the transcriptional activation of hTERT. PMID: 15504359
    14. TEIF could specifically activate transcription of beta-pol promoter, but not that of DNA polymerase alpha or delta promoter. The responsible sequences for binding of TEIF were revealed PMID: 15963946
    15. TEIF functions as a centrosome regulator. Its participation in DNA damage response, including telomere dysfunction and tumorigenesis. PMID: 19198626

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  • 相关疾病：
    Spinocerebellar ataxia, autosomal recessive, 21 (SCAR21)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner.; [Isoform 1]: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.; [Isoform 2]: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.; [Isoform 3]: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner.; [Isoform 6]: Nucleus.
  • 蛋白家族：
    Protein kinase superfamily
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 14372

    OMIM: 607982

    KEGG: hsa:57410

    STRING: 9606.ENSP00000270176

    UniGene: Hs.238839