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SDHAF1 Antibody

  • 货号：
    CSB-PA406800LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA406800LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA406800LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SDHAF1 Polyclonal antibody
  • Uniprot No.：
    A6NFY7
  • 基因名：
    SDHAF1
  • 别名：
    LYR motif containing 8 antibody; LYR motif-containing protein 8 antibody; LYRM8 antibody; mitochondrial antibody; SDH assembly factor 1 antibody; SDHAF1 antibody; SDHF1_HUMAN antibody; Succinate dehydrogenase assembly factor 1 antibody; Succinate dehydrogenase assembly factor 1 mitochondrial antibody; Succinate dehydrogenase complex assembly factor 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Succinate dehydrogenase assembly factor 1, mitochondrial protein (78-115AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SDHAF1 Antibody (CSB-PA406800LA01HU)，的标记方式是Non-conjugated。对于SDHAF1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA406800LB01HU SDHAF1 Antibody, HRP conjugated ELISA
    FITC CSB-PA406800LC01HU SDHAF1 Antibody, FITC conjugated
    Biotin CSB-PA406800LD01HU SDHAF1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20.
  • 基因功能参考文献：
    1. that SDHAF1 contributes to iron-sulfur (Fe-S) cluster incorporation into the Fe-S subunit of CII, SDHB. PMID: 26749241
    2. Studies indicate that an array of tumor syndromes caused by complex II-associated mutations in genes SDHA, SDHB, SDHC, SDHD, SDHAF1 and SDHAF2 have been identified over a decade. PMID: 23174333
    3. Leukoencephalopathy with accumulated succinate is a key symptom of defective complex II assembly due to SDHAF1 mutations PMID: 22995659
  • 相关疾病：
    Mitochondrial complex II deficiency (MT-C2D)
  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Complex I LYR family, SDHAF1 subfamily
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 33867

    OMIM: 252011

    KEGG: hsa:644096

    STRING: 9606.ENSP00000368165

    UniGene: Hs.356460