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SDPR Antibody

  • 货号：
    CSB-PA020919GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O95810
  • 基因名：
    CAVIN2
  • 别名：
    Cavin 2 antibody; Cavin-2 antibody; Phosphatidylserine binding protein antibody; Phosphatidylserine-binding protein antibody; PS p68 antibody; PS-p68 antibody; Sdpr antibody; SDPR_HUMAN antibody; SDR antibody; Serum deprivation response antibody; Serum deprivation response protein antibody; Serum deprivation-response protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SDPR
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae.
  • 基因功能参考文献：
    1. SDPR variants were not associated with major depressive disorder. PMID: 27721187
    2. Overall, these data suggest that Cavin-2 represents a useful marker for discriminating the degree of differentiation in LPS tumors. PMID: 28865960
    3. Data found that CVN2 expression was signi fi cantly down-regulated in oral squamous cell carcinoma (OSCC) in vitro and in vivo and that CVN2 overexpression led to decreased proliferative activities through the CVN2/caveolin-1/ERK path- way. Furthermore, high tumoral progression occurred in CVN2-negative patients with OSCC. PMID: 26086332
    4. Hepatocellular carcinoma patients with lower cavin-2 expression have a relatively poor prognosis. PMID: 27513662
    5. identification of a novel metastasis suppressor gene, serum deprivation response (SDPR), localized to 2q32-33, a region reported to be associated with significant loss of heterozygosity in breast cancer, is reported. PMID: 26739564
    6. Cavin-1 and cavin-2 are strongly expressed within caveolae-like structures within liver sinusoidal endothelial cells of the hepatitis C-related cirrhotic liver and cavin-1 would play a critical role in regulating aspects of caveolin-1. PMID: 26086560
    7. Rather than forming a single coat complex containing the three cavin family members, single-molecule analysis reveals an exquisite specificity of interactions between cavin1, cavin2 and cavin3. PMID: 24473072
    8. Three genes (LY96, IL8 DPR) were significantly downregulated over time. This finding was confirmed in a validation cohort of stroke patients (n=8). PMID: 25124890
    9. The cavin family protein Polymerase 1 and transcript release factor, SRBC and serum deprivation response protein were down regulated in breast cancer cell lines and breast tumor tissue. PMID: 21913217
    10. Study conclude that SDPR is a membrane-curvature-inducing component of caveolae, and that STB-induced membrane tubulation is facilitated by caveolae. PMID: 19525939

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  • 亚细胞定位：
    Cytoplasm, cytosol. Membrane, caveola.
  • 蛋白家族：
    CAVIN family
  • 组织特异性：
    Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.
  • 数据库链接：

    HGNC: 10690

    OMIM: 606728

    KEGG: hsa:8436

    STRING: 9606.ENSP00000305675

    UniGene: Hs.26530