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  4. SEC24C Antibody

SEC24C Antibody

  • 货号：
    CSB-PA020952GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P53992
  • 基因名：
  • 别名：
    Protein transport protein Sec24C antibody; SC 24C antibody; SC24 C antibody; SC24C antibody; SC24C_HUMAN antibody; Sec 24C antibody; Sec24 C antibody; SEC24 related gene family, member C (S. cerevisiae) antibody; SEC24 related protein C antibody; SEC24-related protein C antibody; SEC24C antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SEC24C
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B. May more specifically package GPI-anchored proteins through the cargo receptor TMED10. May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5.
  • 基因功能参考文献：
    1. AKT signaling played a role in ATX secretion regulation to facilitate ATX ER export by enhancing the nuclear factor of activated T cell-mediated p23 (Sec24C) expression PMID: 28298439
    2. Data indicate that a synthetic polypeptide containing the N terminus of bovine AE1 bound the Sec23A-Sec24C complex through a selective interaction with Sec24C. PMID: 23658022
    3. a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C PMID: 23288844
    4. A triple arg motif mediates alpha(2B)-adrenergic receptor interaction with Sec24C/D and export PMID: 22404651
    5. The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C PMID: 21454670
    6. The interphase form of Sec24Cp was O-N-acetylglucosamine modified, a feature lost upon entering into mitosis. This mitotic deglycosylation was coupled to Sec24p phosphorylation, a process which may contribute to observed mitotic ER-to-Golgi traffic block. PMID: 15013749
    7. We found that Sec24C, a component of the host COPII vesicular transport system, interacts specifically with VP40 via VP40 amino acids 303 to 307. PMID: 18329616

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  • 亚细胞定位：
    Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.
  • 蛋白家族：
    SEC23/SEC24 family, SEC24 subfamily
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 10705

    OMIM: 607185

    KEGG: hsa:9632

    STRING: 9606.ENSP00000321845

    UniGene: Hs.81964