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SEC31A Antibody

  • 货号：
    CSB-PA020954GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O94979
  • 基因名：
  • 别名：
    SEC31A antibody; KIAA0905 antibody; SEC31L1 antibody; HSPC275 antibody; HSPC334 antibody; Protein transport protein Sec31A antibody; ABP125 antibody; ABP130 antibody; SEC31-like protein 1 antibody; SEC31-related protein A antibody; Web1-like protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SEC31A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
  • 基因功能参考文献：
    1. USP8 deubiquitinates Sec31A and inhibits the formation of large COPII carriers, thereby suppressing collagen IV secretion. PMID: 29604273
    2. findings suggest that AnxA11 maintains architectural and functional features of the ERES by coordinating with ALG-2 to stabilize Sec31A at the ERES. PMID: 25540196
    3. These results suggest that Sec31 phosphorylation by CK2 controls the duration of COPII vesicle formation, which regulates ER-to-Golgi trafficking. PMID: 23349870
    4. efficient COPII-dependent secretion, notably assembly of Sec13-Sec31, is required to drive epithelial morphogenesis in both two- and three-dimensional cultures PMID: 22331354
    5. SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas. PMID: 21109691
    6. t(4;9)(q21;p24) leads to a novel SEC31A-JAK2 fusion in Hodgkin lymphoma PMID: 21325169
    7. Genomic PCR and subsequent sequencing showed that the breakpoints were located in intron 23 of SEC31L1 and intron 20 of anaplastic lymphoma kinase PMID: 16161041
    8. three-dimensional reconstruction of Sec13/31 cages at 30 A resolution using cryo-electron microscopy and single particle analysis PMID: 16407955
    9. In vitro GST pull down analysis demonstrated that ALG-2 and its alternatively spliced isoform interact with the COPII component Sec31A in a Ca2+-dependent manner, and a biotin-labeled ALG-2 overlay assay revealed direct binding of ALG-2 to Sec31A. PMID: 17196169
    10. The Sec31 active fragment is accommodated in a binding groove supported in part by Sec23 residue Phe380. PMID: 17981133

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  • 相关疾病：
    A chromosomal aberration involving SEC31A is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;4)(p23;q21) with ALK.
  • 亚细胞定位：
    Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasm, cytosol.
  • 蛋白家族：
    WD repeat SEC31 family
  • 组织特异性：
    Abundantly and ubiquitously expressed.
  • 数据库链接：

    HGNC: 17052

    OMIM: 610257

    KEGG: hsa:22872

    STRING: 9606.ENSP00000347329

    UniGene: Hs.370024