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SECISBP2 Antibody

  • 货号：
    CSB-PA020962GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96T21
  • 基因名：
    SECISBP2
  • 别名：
    DKFZp686C09169 antibody; OTTHUMP00000064929 antibody; OTTHUMP00000064930 antibody; OTTHUMP00000064931 antibody; OTTHUMP00000064932 antibody; RP11 89K14.1 antibody; SBP 2 antibody; SBP2 antibody; SEBP2_HUMAN antibody; SECIS binding protein 2 antibody; SECIS-binding protein 2 antibody; SECISBP 2 antibody; SECISBP2 antibody; Selenocysteine insertion sequence binding protein 2 antibody; Selenocysteine insertion sequence-binding protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SECISBP2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
  • 基因功能参考文献：
    1. functions as a vital factor in selenoprotein translation and regulates the pro-oxidant/antioxidant balance in trophoblasts PMID: 28623977
    2. SBP2 interacts directly with four proteins of the SMN complex and the methylosome core proteins. PMID: 28115638
    3. SBP2 makes direct contacts with a discrete region of the human 28S rRNA. PMID: 24850884
    4. The patient showed typical symptoms of SBP2 deficiency, and novel compound heterozygous mutations were identified in SBP2 (p.M515fsX563/p.Q79X). PMID: 22247018
    5. Selenocysteine insertion sequence (SECIS)-binding protein 2 alters conformational dynamics of residues involved in tRNA accommodation in 80 S ribosomes. PMID: 22308032
    6. Describe subjects with compound heterozygous defects in the SECISBP2 gene. These individuals have reduced synthesis of most of the 25 known human selenoproteins, resulting in a complex phenotype. PMID: 21084748
    7. Results demonstrate that SECIS-binding protein 2 is required for protection against reactive oxygen species-induced cellular damage and cell survival. PMID: 19803747
    8. In addition to identifying key amino acids for SECIS recognition by SBP2, our findings led to the proposal that some of the recognition principles governing the 15.5 kD-U4 snRNA interaction must be similar in the SBP2-SECIS RNA complex PMID: 12403468
    9. Oxidative stress induces nuclear accumulation of SBP2 via oxidation of cysteine residues within a redox-sensitive cysteine-rich domain. PMID: 16782878
    10. Data suggest that SBP2 is a major determinant in dictating the hierarchy of selenoprotein synthesis via differential selenoprotein mRNA translation and sensitivity to nonsense-mediated decay. PMID: 17846120
    11. A report of a complex splicing pattern in the 5'-region of human SECISBP2, wherein at least eight splice variants encode five isoforms with varying N-terminal sequence. PMID: 19004874
    12. CUG-BP1 and HuR act as factors that bind to the SBP2 3' UTR, which suggests that TTR-RBPs play a role in the regulation of SBP2 PMID: 19106619
    13. Seleniuim is obviously not a limiting factor in the SBP2 deficient individuals when regular daily selenium intake is provided PMID: 19265499
    14. ca. 70% of the SBP2 sequence is disordered, whereas the RNA binding domain appears to be folded and functional. PMID: 19467292
    15. SBP2 gene mutation producing early arrest in synthesis of full-length molecule. Demonstration that SBP2 isoforms containing all functional domains could be synthesized from three downstream ATGs explains the relatively mild phenotype caused by this defect PMID: 19602558

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  • 相关疾病：
    Abnormal thyroid hormone metabolism (ATHYHM)
  • 亚细胞定位：
    [Isoform 1]: Nucleus.; [Isoform 2]: Mitochondrion.
  • 组织特异性：
    Expressed at high levels in testis.
  • 数据库链接：

    HGNC: 30972

    OMIM: 607693

    KEGG: hsa:79048

    STRING: 9606.ENSP00000364965

    UniGene: Hs.59804