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SELENOW Antibody

  • 货号：
    CSB-PA021034LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA021034LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA021034LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SELENOW Polyclonal antibody
  • Uniprot No.：
    P63302
  • 基因名：
    SELENOW
  • 别名：
    SELENOW antibody; SELW antibody; SEPW1 antibody; Selenoprotein W antibody; SelW antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Selenoprotein W protein (11-86AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SELENOW Antibody (CSB-PA021034LA01HU)，的标记方式是Non-conjugated。对于SELENOW Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021034LB01HU SELENOW Antibody, HRP conjugated ELISA
    FITC CSB-PA021034LC01HU SELENOW Antibody, FITC conjugated
    Biotin CSB-PA021034LD01HU SELENOW Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency.
  • 基因功能参考文献：
    1. The SS concentrations that lead to a decrease in the viability of human prostate adenocarcinoma cells (line Du-145) have been selected, and the effect of sodium selenite on the expression of mRNA of the SELV, SELW, and TGR selenocysteine proteins in these cells has been analyzed. PMID: 29989584
    2. SelW may have a regulatory function in redox cell signaling by interacting with 14-3-3 protein. PMID: 26474786
    3. Suppression of EGFR ubiquitination by SEPW1 may be related to the putative increase in cancer risk associated with high selenium intakes. PMID: 25721765
    4. In response to selenium compounds, SepW1 synthesis increased at the protein and the mRNA levels. PMID: 23830627
    5. p53 was increased in SEPW1 silenced cells and was inversely correlated with SEPW1 mRNA in cell lines with altered SEPW1 expression. PMID: 21866568
    6. The present work shows that SEPW1 facilitates the G1 to S-phase transition by down-regulating expression of the cyclin-dependent kinase inhibitor p21 PMID: 21875573
    7. The gene lacks canonical TATA and CAAT boxes, but has numerous Sp1 consensus binding sites upstream of multiple transcription start sites. SEPW1 is expressed in all of the 22 tissues assayed, and shows highest expression in skeletal muscle and heart. PMID: 12818432
    8. SelW expression in the colon is highly sensitive to Se-depletion PMID: 15670848
    9. SeW is the novel molecular target of MeHg in human neuronal cells and down-regulation of this selenoenzyme by MeHg is dependent not on generation of ROS but on depletion of GSH. PMID: 15823556
    10. SEPW1 mRNA levels were maximal during G1-phase, dropped after the G1/S transition and increased again after G2/M-phase. PMID: 19387567
    11. The small interfering RNA knockdown of BNIP3, IER3, and SEPW1 genes affected critical multiple myeloma endothelial cell functions correlated with the overangiogenic phenotype PMID: 19690192

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    SelWTH family, Selenoprotein W subfamily
  • 组织特异性：
    Ubiquitously expressed with highest levels in skeletal muscle and heart, moderate levels in brain, spinal cord, thyroid, spleen, prostate, ovary, small intestine and colon, and lowest levels in liver and lymph node.
  • 数据库链接：

    HGNC: 10752

    OMIM: 603235

    KEGG: hsa:6415

    STRING: 9606.ENSP00000422644

    UniGene: Hs.631549