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SEMA6A Antibody

  • 货号：
    CSB-PA875655YA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA875655YA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA875655YA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SEMA6A Polyclonal antibody
  • Uniprot No.：
    Q9H2E6
  • 基因名：
    SEMA6A
  • 别名：
    HT018 antibody; SEM6A_HUMAN antibody; SEMA antibody; Sema domain; transmembrane domain (TM); and cytoplasmic domain; (semaphorin) 6A antibody; Sema Q antibody; Sema VIA antibody; SEMA6A 1 antibody; Sema6a antibody; SEMA6A-1 antibody; SEMA6A1 antibody; Semaphorin 6A 1 antibody; Semaphorin Q antibody; Semaphorin VIA antibody; Semaphorin-6A antibody; Semaphorin-6A-1 antibody; SEMAQ antibody; VIA antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Semaphorin-6A protein (755-990AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SEMA6A Antibody (CSB-PA875655YA01HU)，的标记方式是Non-conjugated。对于SEMA6A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA875655YB01HU SEMA6A Antibody, HRP conjugated ELISA
    FITC CSB-PA875655YC01HU SEMA6A Antibody, FITC conjugated
    Biotin CSB-PA875655YD01HU SEMA6A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.; (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium.
  • 基因功能参考文献：
    1. describes the experiments and methods enabling the characterization of Semaphorin 6A as a critical regulator of endothelial cell survival and vessel function PMID: 27787863
    2. miR-203 induces the apoptosis of YD-38 human oral cancer cells by directly targeting SEMA6A. PMID: 28982852
    3. our findings indicated that SEMA6A may be a potential prognostic biomarker in the treatment of Glioblastoma multiforme PMID: 26014517
    4. Data suggest that Sema6A and Mical1 may represent new potential therapeutic targets in BRAFV600E melanoma. PMID: 25576923
    5. We identified the SEMA6A and HLA-DP loci as significant contributors to risk for granulomatosis with polyangiitis. PMID: 23740775
    6. Data show that miR-27a/b regulated the expression of the angiogenesis inhibitor semaphorin 6A (SEMA6A) in vitro and in vivo and targeted the 3'-untranslated region of SEMA6A. PMID: 22184411
    7. Strong expression of SEMA6A is associated with langerhans cells of histiocytosis or dermatopathic lymphadenitis PMID: 16436660
    8. NANOG-, SOX2-, and POU5F1 (OCT3/OCT4)-binding sites within intron 1 of the SEMA6A gene PMID: 17671748
    9. findings suggest for SEMA6A a novel function in the cytoskeleton and a role in modulating tubulin isotype composition and microtubule dynamics PMID: 18187809

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Semaphorin family
  • 数据库链接：

    HGNC: 10738

    OMIM: 605885

    KEGG: hsa:57556

    STRING: 9606.ENSP00000345512

    UniGene: Hs.156967