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  4. SERBP1 Antibody

SERBP1 Antibody

  • 货号：
    CSB-PA021038GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8NC51
  • 基因名：
    SERBP1
  • 别名：
    CGI 55 antibody; CHD3IP antibody; Chromodomain helicase DNA binding protein 3 interacting protein antibody; DKFZp564M2423 antibody; FLJ90489 antibody; HABP4L antibody; PAI 1 mRNA binding protein antibody; PAI RBP1 antibody; PAI-RBP1 antibody; PAI1 RNA-binding protein 1 antibody; PAIRB_HUMAN antibody; PAIRBP1 antibody; Plasminogen activator inhibitor 1 RNA binding protein antibody; Plasminogen activator inhibitor 1 RNA-binding protein antibody; Serbp1 antibody; SERPINE1 mRNA binding protein 1 antibody; SERPINE1 mRNA-binding protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SERBP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation.
  • 基因功能参考文献：
    1. All these results suggested that miR-218/SERBP1 signal pathway could inhibit the malignant phenotype formation and that targeting this pathway may be a potential novel way for HCC therapeutics. PMID: 28369267
    2. Data indicate that serpine1 messenger RNA (mRNA) binding protein 1 (SERBP1) was identified as a downstream target of microRNA miR-26a-5p. PMID: 27449037
    3. SERBP1 is a component of the LRH-1 transcriptional complex. PMID: 26398198
    4. PAI-RBP1 expression level is higher in non-small lung cancer tissues than in normal tissues. PMID: 22373659
    5. Pseudomyogenic haemangioendothelioma consistently displays a SERPINE1-FOSB fusion gene, resulting from a translocation between chromosomes 7 and 19. PMID: 24374978
    6. The RNA-binding protein SERBP1 is abundantly expressed in human breast cancer and may represent a novel breast tumour marker with prognostic significance PMID: 23236990
    7. The RG-rich and RGG box of SERBP1 is asymmetrically dimethylated by PRMT1 and the modification affects protein interaction and intracellular localization of the protein. PMID: 22442049
    8. The 4G allele of the 4G/5G polymorphism in the PAI-1 gene may be a risk factor for IgE-mediated asthma and allergic diseases. PMID: 11972486
    9. Polymorphism of the PAI-1 gene promoter does not influence the development of AAA. However, the effect of PAI-1 genotype (5G5G) appears protective on survival following open aneurysm repair. PMID: 12027469
    10. We observed that CGI-55 localizes to the nucleolus and co-localizes with p80-coilin positive nuclear-coiled bodies. PMID: 16679534
    11. Has two conserved Gly/Arg-rich motif clusters (RGG/RXR box, where X is any amino acid) that may be substrates for arginine-methylation by protein arginine-methyltransferase-1 (PRMT1). PMID: 16879614
    12. The presence of the genotype risk factors alone does not seem to be associated with the development of preeclampsia even in the severe presentation form. PAI-1 gene polymorphisms on the development of the preeclampsia was indicated. PMID: 16963292
    13. In ovarian cancer, PAI-RBP1 is significantly overexpressed in tumor epithelial cells, suggesting a biological role in tumor invasion and metastasis. Its expression is higher in advanced disease. PMID: 17698176
    14. This gene encodes a protein, PAI-RBP1, that binds to an RNA sequence (cyclic nucleotide responsive sequence, CRS) in the plasminogen activator-inhibitor (PAI-1) mRNA that confers cAMP regulation of mRNA stability. PMID: 11001948

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, perinuclear region.
  • 组织特异性：
    Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain.
  • 数据库链接：

    HGNC: 17860

    OMIM: 607378

    KEGG: hsa:26135

    STRING: 9606.ENSP00000360034

    UniGene: Hs.530412