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SERPINB6 Antibody

  • 货号：
    CSB-PA021074ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SERPINB6 antibody at 0.4µg/ml
      Lane 1: Human placenta tissue
      Lane 2: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 43 kDa
      Observed band size: 43 kDa
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA021074ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SERPINB6 Polyclonal antibody
  • Uniprot No.：
    P35237
  • 基因名：
    SERPINB6
  • 别名：
    CAP antibody; Cytoplasmic antiproteinase antibody; Peptidase inhibitor 6 antibody; PI-6 antibody; PI6 antibody; Placental thrombin inhibitor antibody; Protease inhibitor 6 (placental thrombin inhibitor) antibody; PTI antibody; Serpin B6 antibody; SERPINB6 antibody; SPB6_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Serpin B6 protein (180-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
  • 基因功能参考文献：
    1. A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss. PMID: 20451170
    2. In mast cells, SERPINB6 serves to regulate the activity of endogenous beta-tryptase in the cytoplasm. PMID: 14670919
    3. Expressed in developing gonads and in both somatic and germ cells of adult gonads. PMID: 16175637
    4. Protects the intracellular compartment of keratinocytes from ectopic kallikrein-8. PMID: 17761692
    5. the discovery overexpression of GPD1 and RRBP1 proteins and lack of expression for HNRNPH1 and SERPINB6 proteins which are new candidate biomarkers of colon cancer. PMID: 19425502

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  • 相关疾病：
    Deafness, autosomal recessive, 91 (DFNB91)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Serpin family, Ov-serpin subfamily
  • 组织特异性：
    Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissu
  • 数据库链接：

    HGNC: 8950

    OMIM: 173321

    KEGG: hsa:5269

    STRING: 9606.ENSP00000338358

    UniGene: Hs.519523