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SETD1B Antibody

  • 货号：
    CSB-PA021102GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UPS6
  • 基因名：
    SETD1B
  • 别名：
    FLJ20803 antibody; Histone-lysine N-methyltransferase SETD1B antibody; hSET1B antibody; KIAA1076 antibody; KMT2G antibody; Lysine N-methyltransferase 2G antibody; SET domain containing 1B antibody; SET domain-containing protein 1B antibody; SET1B antibody; SET1B_HUMAN antibody; SETD1B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SETD1B
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis.
  • 基因功能参考文献：
    1. KMT2G levels were higher in metastatic clear cell renal cell carcinomas and may be a good marker for discriminating metastatic tumors from non-metastatic tumors. PMID: 29944950
    2. report the existence of a cytoplasmic form of SET1B/COMPASS, which is essential for maintaining breast tumor cell viability and promotes cell growth. PMID: 29138278
    3. we propose histone demethylase KDM2B and histone methyltransferase SETD1B as the two most plausible candidate genes involved in intellectual disability, autism, epilepsy, and craniofacial anomalies PMID: 27106595
    4. We analyzed SETD1B expression in gastric and colorectal cancer. Loss of SETD1B was identified in 15% to 55% of the GC and CRC with respect to the microsatellite instability status. Loss of expression was more common in those with SETD1B mutations. PMID: 24925220
    5. both Rbm15 and the leukemogenic Rbm15-Mkl1 fusion protein interact with the Setd1b histone H3-Lys4 methyltransferase PMID: 22927943

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  • 亚细胞定位：
    Nucleus speckle. Chromosome. Note=Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily
  • 数据库链接：

    HGNC: 29187

    OMIM: 611055

    STRING: 9606.ENSP00000267197

    UniGene: Hs.507122