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SF3A1 Antibody

  • 货号：
    CSB-PA021121GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q15459
  • 基因名：
    SF3A1
  • 别名：
    Pre mRNA processing 21 antibody; Pre mRNA splicing factor SF3a antibody; PRP21 antibody; PRPF21 antibody; SAP 114 antibody; SAP114 antibody; sf3a1 antibody; SF3A1_HUMAN antibody; SF3a120 antibody; Spliceosome associated protein 114 antibody; Spliceosome-associated protein 114 antibody; Splicing factor 3 subunit 1 antibody; Splicing factor 3a subunit 1 120kDa antibody; Splicing factor 3A subunit 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SF3A1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes.
  • 基因功能参考文献：
    1. Polymorphisms in SF3A1 gene is associated with pancreatic cancer. PMID: 26498691
    2. SF3A1 polymorphisms are not associated with Colorectal Cancer Risk. PMID: 26079486
    3. the SF3A mRNA splicing complex controls production of a negative regulator of TLR signaling that limits the extent of innate immune activation. PMID: 24204290
    4. show that U1-SL4 interacts with the SF3A1 protein of the U2 snRNP PMID: 25403181
    5. SF3a60, 66, and 120, but not SF1, are essential for pre-mRNA splicing PMID: 15647371

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  • 亚细胞定位：
    Nucleus. Nucleus speckle.
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 10765

    OMIM: 605595

    KEGG: hsa:10291

    STRING: 9606.ENSP00000215793

    UniGene: Hs.406277