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SF3B6 Antibody

  • 货号：
    CSB-PA897543LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA897543LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SF3B6 Polyclonal antibody
  • Uniprot No.：
    Q9Y3B4
  • 基因名：
    SF3B6
  • 别名：
    Ht006 antibody; P14 antibody; PM14_HUMAN antibody; Pre mRNA branch site protein p14 antibody; Pre-mRNA branch site protein p14 antibody; SAP14 antibody; SF3B 14 kDa subunit antibody; SF3B14 antibody; SF3B14a antibody; Splicing factor 3B, 14 kDa subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Splicing factor 3B subunit 6 protein (1-125AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SF3B6 Antibody (CSB-PA897543LA01HU)，的标记方式是Non-conjugated。对于SF3B6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA897543LB01HU SF3B6 Antibody, HRP conjugated ELISA
    FITC CSB-PA897543LC01HU SF3B6 Antibody, FITC conjugated
    Biotin CSB-PA897543LD01HU SF3B6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively.
  • 基因功能参考文献：
    1. the p14-RNA interaction screens charges on the backbone of the branch site during spliceosome assembly. PMID: 26784522
    2. determined the high resolution structure of a complex between SF3b14 and a peptide derived from SF3b155 and proposed a model for recognition of the pre-mRNA branch sequence adenosine. PMID: 16432215
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    SF3B6 family
  • 数据库链接：

    HGNC: 30096

    OMIM: 607835

    KEGG: hsa:51639

    STRING: 9606.ENSP00000233468

    UniGene: Hs.177861