SGCB Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) SGCB Polyclonal antibody
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Uniprot No.:Q16585
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基因名:SGCB
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别名:43 kDa dystrophin associated glycoprotein antibody; 43 kDa dystrophin-associated glycoprotein antibody; 43DAG antibody; A3b antibody; Beta SG antibody; Beta-sarcoglycan antibody; Beta-SG antibody; dystrophin-associated glycoprotein, 43-kD antibody; LGMD2E antibody; Limb girdle muscular dystrophy 2E (non linked families) antibody; Sarcoglycan beta antibody; sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) antibody; SGC antibody; SGCB antibody; SGCB_HUMAN antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human Beta-sarcoglycan protein (124-219AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,SGCB Antibody (CSB-PA618082LA01HU),的标记方式是Non-conjugated。对于SGCB Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, IHC, IF
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推荐稀释比:
Application Recommended Dilution IHC 1:500-1:1000 IF 1:200-1:500 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
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基因功能参考文献:
- This study demonstrated that LGMD2E is the most common type of sarcoglycanopathies in the Iranian population. PMID: 28687063
- Clinical severity of limb-girdle muscular dystrophy type 2Emay be predicted by SGCB gene mutation and sarcoglycan protein expression. PMID: 25862795
- Defective assembly of sarcoglycan complex in patients with beta-sarcoglycan gene mutations PMID: 12060343
- beta-sarcoglycan and SPATA18 may have a role in limb-girdle muscular dystrophy type 2E PMID: 16088906
- While the quantity of beta-sarcoglycan was nearly normal in the limb girdle muscular dystrophy (LGMD)2E carrier, the levels of dysferlin protein were reduced to 50% of controls in the carriers of LGMD2B. PMID: 16934466
- These data suggest that formation of the beta-delta-core may promote the export and deposition of sarcoglycan subcomplexes at the plasma membrane, and therefore identifies a mechanism for sarcoglycan transport. PMID: 17036316
- The limb-girdle muscular dystrophy patients with beta-sarcoglycan deficient LGMD2E do not enable an accurate prediction of the genotype. PMID: 18996010
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相关疾病:Limb-girdle muscular dystrophy 2E (LGMD2E)
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亚细胞定位:Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.
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蛋白家族:Sarcoglycan beta/delta/gamma/zeta family
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组织特异性:Highest expression in heart and skeletal muscle. Low expression in brain, kidney, placenta, pancreas and lung. High expression in fetal brain. Also found in fetal lung, kidney and liver.
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数据库链接:
HGNC: 10806
OMIM: 600900
KEGG: hsa:6443
STRING: 9606.ENSP00000370839
UniGene: Hs.438953