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SH2D3C Antibody

  • 货号：
    CSB-PA021213GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8N5H7
  • 基因名：
    SH2D3C
  • 别名：
    Cas/HEF1 associated signal transducer antibody; CHAT antibody; FLJ39664 antibody; Novel SH2 containing protein 3 antibody; Novel SH2-containing protein 3 antibody; NSP 3 antibody; PRO34088 antibody; SH2 domain containing 3C antibody; SH2 domain containing Eph receptor binding protein 1 antibody; SH2 domain containing protein 3C antibody; SH2 domain-containing protein 3C antibody; SH2D3_HUMAN antibody; SH2D3C antibody; Shep1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SH2D3C
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response. Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1. Promotes cell migration and invasion through the extracellular matrix. Required for marginal zone B-cell development and thymus-independent type 2 immune responses. Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL. Plays a role in CXCL13-induced chemotaxis of B-cells. Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development. Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons.; Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1. Required for tissue-specific adhesion of T lymphocytes to peripheral tissues. Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9. May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells.; May be involved in the BCAR1/CAS-mediated JNK activation pathway.
  • 基因功能参考文献：
    1. The structure of the NSP3-p130Cas complex reveals that this closed conformation is instrumental for interaction of NSP proteins with a focal adhesion-targeting domain present in Cas proteins. PMID: 22081014
    2. This protein positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells. PMID: 12486027
    3. SH2D3C (SHEP1) is less highly expressed than BCAR3 and NSP1 in breast cancer cells, and the expression patterns suggest differential roles for the three genes during breast cancer progression. PMID: 17270363
    4. NSP3 overexpression did not induce anti-estrogen resistance in breast tumor cell lines. PMID: 17427198
  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein. Cell projection, axon. Cell projection, ruffle membrane.; [Isoform 1]: Cell membrane; Peripheral membrane protein.
  • 组织特异性：
    [Isoform 1]: Ubiquitously expressed.
  • 数据库链接：

    HGNC: 16884

    OMIM: 604722

    KEGG: hsa:10044

    STRING: 9606.ENSP00000317817

    UniGene: Hs.306412