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SH3BP5 Antibody

  • 货号：
    CSB-PA021226LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse heart tissue, Mouse brain tissue, Mouse kidney tissue
      All lanes: SH3BP5 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 51, 33 kDa
      Observed band size: 51 kDa
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA021226LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA021226LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate, U87 whole cell lysate
      All lanes: SH3BP5 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 51, 33 kDa
      Observed band size: 51 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SH3BP5 Polyclonal antibody
  • Uniprot No.：
    O60239
  • 基因名：
    SH3BP5
  • 别名：
    3BP5_HUMAN antibody; OTTHUMP00000208289 antibody; OTTHUMP00000208291 antibody; OTTHUMP00000208294 antibody; SAB antibody; SH3 binding protein antibody; SH3 domain binding protein 5 (BTK associated) antibody; SH3 domain binding protein 5 antibody; SH3 domain binding protein that preferentially associates with BTK antibody; SH3 domain-binding protein 5 antibody; SH3 domain-binding protein that preferentially associates with BTK antibody; SH3 domainbinding protein 5 antibody; SH3BP 5 antibody; SH3BP-5 antibody; Sh3bp5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human SH3 domain-binding protein 5 protein (49-455AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SH3BP5 Antibody (CSB-PA021226LA01HU)，的标记方式是Non-conjugated。对于SH3BP5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021226LB01HU SH3BP5 Antibody, HRP conjugated ELISA
    FITC CSB-PA021226LC01HU SH3BP5 Antibody, FITC conjugated
    Biotin CSB-PA021226LD01HU SH3BP5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:2000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
  • 基因功能参考文献：
    1. SH3BP5, LMO3, and SNAP25 were expressed in diffuse large B-cell lymphoma cells and associated with clinical features. PMID: 27184832
    2. REI/SH3BP5 protein family is conserved in evolution and is a group of new guanine nucleotide exchange factors for Rab11. PMID: 26745340
    3. The interplay of p-JNK with mitochondrial Sab leads to impaired respiration, ROS production, sustained JNK activation, and apoptosis. PMID: 25666017
    4. SH3BP5 binds to JNK and directly inhibits JNK through its two putative mitogen-activated protein kinase interaction motifs (KIMs). PMID: 23861391
    5. mitochondrial protein Sab is phosphorylated by stress-activated protein kinase 3 PMID: 15158451

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  • 亚细胞定位：
    Cytoplasmic vesicle membrane; Peripheral membrane protein. Mitochondrion.
  • 蛋白家族：
    SH3BP5 family
  • 组织特异性：
    Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.
  • 数据库链接：

    HGNC: 10827

    OMIM: 605612

    KEGG: hsa:9467

    STRING: 9606.ENSP00000373301

    UniGene: Hs.257761