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SHC2 Antibody

  • 货号：
    CSB-PA008569
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P98077
  • 基因名：
  • 别名：
    SHC2 antibody; SCK antibody; SHCB antibody; SHC-transforming protein 2 antibody; Protein Sck antibody; SHC-transforming protein B antibody; Src homology 2 domain-containing-transforming protein C2 antibody; SH2 domain protein C2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Sck.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
  • 基因功能参考文献：
    1. Sck was identified as a novel molecule indispensable for CD95's activation of the PI3K and MAPK pathways and induction of cell cycle progression in pancreatic ductal adenocarcinoma. PMID: 25613377
    2. SHC2 gene deletions underlie few, if any, cases of well-characterized multiple system atrophy in the US population. PMID: 24170347
    3. Data show that copy number loss of SHC2 strongly indicates a causal link to multiple system atrophy. PMID: 21658278
  • 组织特异性：
    Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.
  • 数据库链接：

    HGNC: 29869

    OMIM: 605217

    KEGG: hsa:25759

    STRING: 9606.ENSP00000264554

    UniGene: Hs.30965