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SHC3 Antibody

  • 货号：
    CSB-PA838779LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: U87 whole cell lysate, Mouse lung tissue
      All lanes: SHC3 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 65, 52 kDa
      Observed band size: 65 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SHC3 Polyclonal antibody
  • Uniprot No.：
    Q92529
  • 基因名：
  • 别名：
    N SHC antibody; N-Shc antibody; Neuronal Shc antibody; NSHC antibody; Protein Rai antibody; Rai antibody; SH2 domain protein C3 antibody; SHC (Src homology 2 domain containing) transforming protein 3 antibody; SHC adaptor protein 3 antibody; SHC protein C antibody; SHC-like protein, neuronal antibody; SHC-transforming protein 3 antibody; SHC-transforming protein C antibody; Shc3 antibody; Shc3 p51 antibody; SHC3_HUMAN antibody; SHCC antibody; Src homology 2 domain-containing transforming protein antibody; Src homology 2 domain-containing-transforming protein C3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human SHC-transforming protein 3 protein (323-468AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SHC3 Antibody (CSB-PA838779LA01HU)，的标记方式是Non-conjugated。对于SHC3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA838779LB01HU SHC3 Antibody, HRP conjugated ELISA
    FITC CSB-PA838779LC01HU SHC3 Antibody, FITC conjugated
    Biotin CSB-PA838779LD01HU SHC3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
  • 基因功能参考文献：
    1. High SHC3 expression is associated with glioblastoma. PMID: 25062668
    2. Rai (ShcC/N-Shc), a member of the family of Shc-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells. PMID: 22311806
    3. Polymorphism in RAI and CD3EAP are associated with outcome of myeloma patients treated with high dose treatment. PMID: 21046104
    4. amplification of SHC3 and EDG3 genes suggests that the two proteins co-operate and are important for ependymomas in vivo. PMID: 19748727
    5. Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. PMID: 11877420
    6. ALK-ShcC signal activation, possibly caused by co-amplification with the N-myc gene, might give additional effects on malignant tumor progression of neuroblastoma.ShcC is a potent substrate of the activated ALK kinase. PMID: 12185581
    7. The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway. PMID: 12242309
    8. ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma cells PMID: 15735675
    9. The inappropriate in vivo expression of Shc3 in high-grade glioma may contribute to the survival of the cancer cells. PMID: 15870690
    10. data suggest that RAI (ShcC/H-Shc)is a critical substrate for RET oncoproteins in thyroid carcinomas PMID: 15940252
    11. 11 SNPs within SHC3 were examined to determine the association with nicotine dependence (ND) in either African-Americans (AA) or European-Americans (EA); three SNPs for AAs and one for EAs were significantly associated with at least one ND. PMID: 17179996
    12. shcc is expressed in the human gut, especially in the enteric glial cells PMID: 17919311
    13. ShcC is a therapeutic target that might induce differentiation in the aggressive type of neuroblastomas. PMID: 18997821

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  • 组织特异性：
    Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, me
  • 数据库链接：

    HGNC: 18181

    OMIM: 605263

    KEGG: hsa:53358

    STRING: 9606.ENSP00000364995

    UniGene: Hs.292737