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SHOX2 Antibody

  • 货号：
    CSB-PA021277ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA021277ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA021277ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SHOX2 Polyclonal antibody
  • Uniprot No.：
    O60902
  • 基因名：
    SHOX2
  • 别名：
    Homeobox protein Og12X antibody; OG 12 antibody; OG 12X antibody; OG12 antibody; OG12X antibody; OGI 2X antibody; OGI2X antibody; Paired related homeobox protein SHOT antibody; Paired-related homeobox protein SHOT antibody; Short stature homeobox 2 antibody; Short stature homeobox homolog antibody; Short stature homeobox protein 2 antibody; SHOT antibody; SHOX 2 antibody; SHOX homologous gene on chromosome 3 antibody; SHOX2 antibody; SHOX2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Short stature homeobox protein 2 protein (72-331AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.
  • 基因功能参考文献：
    1. the methylation positive rates of SHOX2 with RASSF1A in stage III were both higher than the other stages of lung cancer PMID: 28325362
    2. High SHOX2 methylation is associated with Lung cancer. PMID: 27544059
    3. important role in the process of intervertebral disc degeneration PMID: 26697824
    4. Data suggest that the microRNA miR-375/short stature homeobox 2 protein (SHOX2) axis may be a novel therapeutic target for esophageal squamous cell carcinoma (ESCC). PMID: 28069583
    5. Study showed that SHOX2 methylation levels in adenomas and colorectal carcinomas (CRC) were significantly higher compared to those in normal control tissues. Histologic transition from adenomas to CRC was paralleled by amplification of the SEPT9 gene locus. PMID: 27660666
    6. Study found SHOX2 and SEPT9 frequently methylated in biliary tract cancers. PMID: 27999621
    7. We have identified that SHOX2 expression or methylation are potent independent prognostic indicators for predicting LGG patient survival, and have potential to identify an important subset of LGG patients with IDHwt status with significantly better overall survival. PMID: 27840009
    8. Whole-genome microarray mRNA-expression profiles of myofibroblasts and skin fibroblasts revealed four additional genes that are significantly differentially expressed in these two cell types: NKX2-3 and LRRC17 in myofibroblasts and SHOX2 and TBX5 in skin fibroblasts PMID: 27036009
    9. these results suggest a genetic contribution of SHOX2 in early-onset atrial fibrillation PMID: 27138930
    10. The longitudinal measurement of extracellular plasma mSHOX2 DNA yields information about the response to cytotoxic treatment and allows an early assessment of treatment response for lung cancer patients. PMID: 25675432
    11. SHOX2 overexpression favors differentiation of embryonic stem cells into cardiac pacemaker cells, improving biological pacing ability. PMID: 25533636
    12. SHOX2 DNA methylation identified 66% of the patients with cancer subsequent to a cytological equivocal diagnosis. SHOX2 complements the cytological diagnosis and the methylation marker panel. PMID: 25331797
    13. miR-375/SHOX2 functional relationship regulates breast tumorigenesis by controlling the process of EMT. PMID: 24746361
    14. SHOX2, like SHOX, regulates NPPB directly whilst activates ACAN via its cooperation with the SOX trio. PMID: 24421874
    15. prognostic value of SHOX2 and SEPT9 DNA methylation in benign, paramalignant and malignant pleural effusions PMID: 24386354
    16. Elevated SHOX2 expression is associated with tumor recurrence of hepatocellular carcinoma. PMID: 23851611
    17. The combination of EBUS-TBNA and SHOX2 methylation level strongly improves the assessment of the nodal status by identifying additional malignant lesions and confirming benign nodes and therefore avoiding invasive follow-up procedures. PMID: 24026539
    18. The assay is based on quantification of methylated Short Stature Homeobox gene two (SHOX2) DNA in the specimen measured via multiplex real-time Polymerase Chain Reaction (PCR) on bisulfite-converted DNA. PMID: 24136974
    19. Shox2 regulates progression through chondrogenesis at two distinct stages--the onset of early differentiation and the transition to maturation and hypertrophy. PMID: 23038774
    20. DNA methylation of PITX2 and SHOX2 is an independent prognostic biomarker for disease progression in non-small-cell lung cancer patients. PMID: 22555092
    21. A CE marked in vitro diagnostic test kit to quantify SHOX2 DNA methylation in bronchial aspirates was developed and characterized. PMID: 22108652
    22. SHOX2 DNA methylation is associated with lung cancer. PMID: 21694641
    23. Frequent gene amplification correlated with hypermethylation of the SHOX2 gene locus. PMID: 21426551
    24. work establishes a link between Tbx5, Shox2 and Bmp4 in the pacemaker region of the developing heart PMID: 20858598
    25. SHOX2 DNA methylation is found in bronchial aspirates of lung cancer patients PMID: 21047392

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family, Bicoid subfamily
  • 组织特异性：
    Expressed in heart, skeletal muscle, liver, lung, bone marrow fibroblast, pancreas and placenta.
  • 数据库链接：

    HGNC: 10854

    OMIM: 602504

    KEGG: hsa:6474

    STRING: 9606.ENSP00000419362

    UniGene: Hs.55967