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SHROOM2 Antibody

  • 货号：
    CSB-PA622684LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA622684LA01HU diluted at 1:200 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of MCF-7 cells with CSB-PA622684LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SHROOM2 Polyclonal antibody
  • Uniprot No.：
    Q13796
  • 基因名：
    SHROOM2
  • 别名：
    4832440C16 antibody; Ab2-404 antibody; Apical like protein antibody; Apical like protein APXL protein antibody; apical protein of Xenopus-like antibody; Apical protein Xenopus laevis like antibody; apical protein, Xenopus laevis-like antibody; apical protein-like antibody; apical protein-like (Xenopus laevis) antibody; Apical-like protein antibody; APX homolog of Xenopus antibody; C630003H05Rik antibody; DKFZp781J074 antibody; FLJ39277 antibody; HSAPXL antibody; Liver regeneration-related protein LRRG167 antibody; OTTHUMP00000022887 antibody; Protein Apxl antibody; Protein Shroom2 antibody; Shrm2 antibody; SHRM2_HUMAN antibody; SHROOM 2 antibody; Shroom family member 2 antibody; shroom2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein Shroom2 protein (213-405AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SHROOM2 Antibody (CSB-PA622684LA01HU)，的标记方式是Non-conjugated。对于SHROOM2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA622684LB01HU SHROOM2 Antibody, HRP conjugated ELISA
    FITC CSB-PA622684LC01HU SHROOM2 Antibody, FITC conjugated
    Biotin CSB-PA622684LD01HU SHROOM2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution.
  • 基因功能参考文献：
    1. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 x 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 x 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 x 10(-10)). PMID: 22634755
    2. Data suggest that Shroom2 facilitates the formation of a contractile network within endothelial cells, the loss of which leads to an increase in endothelial sprouting, migration, and angiogenesis. PMID: 21248203
  • 亚细胞定位：
    Apical cell membrane. Cell junction, tight junction. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Shroom family
  • 组织特异性：
    Abundant in retina and melanoma; also in brain, placenta, lung, kidney and pancreas.
  • 数据库链接：

    HGNC: 630

    OMIM: 300103

    KEGG: hsa:357

    STRING: 9606.ENSP00000370299

    UniGene: Hs.567236