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SIK3 Antibody

  • 货号：
    CSB-PA897531ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA897531ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA897531ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SIK3 Polyclonal antibody
  • Uniprot No.：
    Q9Y2K2
  • 基因名：
    SIK3
  • 别名：
    SIK3 antibody; KIAA0999 antibody; QSK antibody; L19Serine/threonine-protein kinase SIK3 antibody; EC 2.7.11.1 antibody; Salt-inducible kinase 3 antibody; SIK-3 antibody; Serine/threonine-protein kinase QSK antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase SIK3 protein (60-310AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3. Prevents HDAC4 translocation to the nucleus.
  • 基因功能参考文献：
    1. role in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation PMID: 28658303
    2. Results found that CpG sites of C1orf106, DMBX1, and SIK3 mediate the genetic risk of psoriasis in Chinese Han population. PMID: 27980695
    3. SIK3 is activated in human osteoarthritic cartilage. PMID: 27009967
    4. Developmental role of Sik3 in hearing and requirement for the maintenance of adult auditory function is reported. PMID: 25060954
    5. SIK3 variants were associated with hypertriglyceridemia in Mexicans. PMID: 24886709
    6. These results establish the importance of SIK3 as a mitotic regulator and underscore the potential of SIK3 as a druggable antimitotic target. PMID: 24743732
    7. cAMP-mediated regulation of SIK3 suggest that SIK3 may mediate some of the effects of this important second messenger in adipocytes PMID: 22588126
    8. Overexpression of SIK3 promotes G1/S cell cycle progression, bestows survival advantages to cancer cells for growth and correlates the clinicopathological conditions of patients with ovarian cancer. PMID: 21399663
    9. Fecal ribosomal protein L19 is a genetic prognostic factor for survival in colorectal cancer. PMID: 18266979

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
  • 组织特异性：
    Expressed in chondrocytes.
  • 数据库链接：

    HGNC: 29165

    OMIM: 614776

    KEGG: hsa:23387

    STRING: 9606.ENSP00000292055

    UniGene: Hs.167451