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SIN3B Antibody

  • 货号：
    CSB-PA021328LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA021328LA01HU diluted at 1:400 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system.
    • Immunofluorescence staining of Hela cells with CSB-PA021328LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SIN3B Polyclonal antibody
  • Uniprot No.：
    O75182
  • 基因名：
    SIN3B
  • 别名：
    SIN3B antibody; KIAA0700 antibody; Paired amphipathic helix protein Sin3b antibody; Histone deacetylase complex subunit Sin3b antibody; Transcriptional corepressor Sin3b antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Paired amphipathic helix protein Sin3b protein (705-769AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SIN3B Antibody (CSB-PA021328LA01HU)，的标记方式是Non-conjugated。对于SIN3B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021328LB01HU SIN3B Antibody, HRP conjugated ELISA
    FITC CSB-PA021328LC01HU SIN3B Antibody, FITC conjugated
    Biotin CSB-PA021328LD01HU SIN3B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.
  • 基因功能参考文献：
    1. High mRNA expression of SIN3A/low mRNA expression of SIN3B correlates with longer relapse free survival specifically in patients with triple negative breast cancer. PMID: 27780928
    2. Low SIN3B expression is associated with Prostate Cancer Progression. PMID: 28807943
    3. these results suggest that stress-induced Sin3B activation is p53-dependent and is essential for p53-mediated repression of its selective target genes. PMID: 26181367
    4. The study suggests that the difference in the conformation of native state structure or structural flexibility of the paired amphi pathic helices (PAH) domains of Sin3B might be responsible for interacting with specific binding partners. PMID: 25869359
    5. A conserved Myc region (amino acids 186-203) is required for the interaction with Sin3 proteins. Histone deacetylase 1 is recruited to Myc-Sin3b complexes, and its deacetylase activity is required for the effects of Sin3b on Myc. PMID: 24951594
    6. this study highlights an essential role for Sin3B in IFN-c induced COL1A2 repression in smooth muscle cells. PMID: 24709079
    7. Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression PMID: 24691445
    8. the essential role of Sin3B as an important associate of p53 in mediating the cellular responses to stress and in the transcriptional repression of genes PMID: 22028823
    9. identification of a mammalian complex containing the corepressor Sin3B, the histone deacetylase HDAC1, Mrg15, and the PHD finger-containing Pf1 PMID: 21041482
    10. disruption of the function of a specific Sin3A/B domain leads to epigenetic reprogramming and derepression of specific subsets of genes in breast cancer cells PMID: 20547842
    11. SMAR1 regulates cyclin D1 by modification of chromatin through the SIN3/histone deacetylase 1 complex PMID: 16166625
    12. The interaction between SIN3B and ETO required an intact amino-terminus of ETO and the NHR2 domain. PMID: 18205948
    13. ETO family member-mediated oligomerization and repression can be distinct events and that interaction between ETO family members and hSIN3B or N-CoR may not necessarily strengthen transcriptional repression. PMID: 18586123
    14. Modulation of Sin3B-associated activities may represent new therapeutic opportunities for treatment of cancers. PMID: 19654306

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 19354

    OMIM: 607777

    KEGG: hsa:23309

    STRING: 9606.ENSP00000369131

    UniGene: Hs.13999