SLAMF1 Antibody

1. CD150 and CD180 receptors may modulate transcriptional program in lymphocytic leukemia cells by regulating the transcription factor expression levels PMID: 29284783
2. this paper shows that the X-linked lymphoproliferative disease gene product SAP regulates signals induced through the co-receptor SLAM PMID: 28827385
3. combination of signals via CD150 and CD180 leads to blocking of pro-survival pathways that may be a restraining factor for neoplastic CLL B cells propagation in more than 50% of CLL cases where these receptors are coexpressed PMID: 28982149
4. EBF1 is critical for transcriptional control of SLAMF1 gene in human B cells. PMID: 27424222
5. MeV can hijack SLAMF1 to drive endocytosis using a complex pathway that shares features with canonical viral macropinocytosis, phagocytosis, and mechanotransduction. This uptake pathway is specific to SLAMF1-positive cells and occurs within 60 min of viral attachment. PMID: 28100610
6. Malignant B-cell lines at the different stages of maturation only partially resemble their normal counterparts by CD150 expression. In malignant B-cell lines, CD150 expression on mRNA level is much broader than on protein level. CD150 isoforms are differentially expressed in normal and malignant B cells with predominant expression of mCD150 isoform. PMID: 27356578
7. Data suggest that SLAMF1 is another significant piece in the intricate defective immune-regulatory function of patients with SLE. PMID: 25920347
8. results indicate that loss of SLAMF1 expression in chronic lymphocytic leukemia modulates genetic pathways PMID: 26619119
9. Upstream open reading frames regulate translation of the long isoform of SLAMF1 mRNA that encodes costimulatory receptor CD150 PMID: 25716736
10. Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM peptide. PMID: 24770789
11. Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance. PMID: 24373350
12. Latent membrane protein 1 was responsible for the CD150 upregulation. PMID: 24238277
13. Experimental adaptation of wild-type canine distemper virus (CDV) to the human entry receptor CD150 PMID: 23554862
14. conclude that Slamf1 recruits a subset of Vps34-associated proteins, which is involved in membrane fusion and NOX2 regulation PMID: 22493499
15. HIV-1 infection induces a high level of SLAM expression on CD4(+) T cells, which may enhance their susceptibility to measles virus and exacerbate measles in coinfected individuals. PMID: 22532682
16. the study demonstrates that variants of SLAMF1 and ITLN1, both implicated in inflammation, are associated with type 2 diabetes in Indians. PMID: 22277902
17. Subjects previously immunized with measles-mumps-rubella vaccine were genotyped for 66 candidate single nucleotide polymorphisms in the CD46, SLAM and CD209 genes. PMID: 22086389
18. The simultaneous interaction of Measles virus glycoprotein-pseudotyped Lentivirus with both CD46 and SLAM is required to achieve efficient and stable transduction of B and T cells. PMID: 21450813
19. CD150 receptor could trigger PI3K-mediated Akt signaling pathway in normal, EBV-transformed and malignant B cells. PMID: 21423089
20. A role for SLAM in controlling natural killer T (NKT) cell development is consistent with a role in both positive and negative thymic selection of NKT cells in NOD mice. PMID: 21357537
21. Our findings suggest that -262A-188G haplotype in the SLAM gene promoter contributes to the risk of systemic lupus erythematosus by increasing the expression of SLAM. PMID: 20810499
22. CD150 may contribute to regulation of tumor cell maintenance in low-rate proliferating Hodgkin's lymphoma PMID: 20231852
23. Apoptosis of measles virus-infected peripheral blood mononuclear cells is triggered by interaction between viral hemagglutinin protein and cellular receptor, SLAM. PMID: 20618687
24. Data show that measles virus infection of alveolar macrophages and subepithelial dendritic cells in the airways precedes infection of lymphocytes in lymphatic organs of mice expressing human SLAM with human-like tissue specificity. PMID: 20042501
25. Susceptibility of human dendritic cells (DCs) to measles virus (MV) depends on their activation stages in conjunction with the level of CDw150: role of Toll stimulators in DC maturation and MV amplification PMID: 12270725
26. effect of X-linked lymphoproliferative syndrome gene product SAP/SH2D1A on signaling through signaling lymphocyte activation molecule family of immune receptors PMID: 12458214
27. direct correlation between the amount of hSLAM expressed on the cells' surface and the degree of measles virus infection; MV infection induced downregulation of receptor hSLAM and inhibited cell division and proliferation of hSLAM(+)T cells PMID: 12610126
28. SLAM mRNA expression in PBMC is modulated during the course of specific immunotherapy, and an early and transient increase of SLAM mRNA expression is associated with clinical symptom improvement PMID: 14657878
29. SLAM expression correlates directly with T cell responsiveness to Mycobacterium tuberculosis antigen. PMID: 14707094
30. murine Measles virus-infected dendritic cells expressing hSLAM receptor downregulated B7-1, B7-2, CD40, MHC class I, and MHC class II expresssion on their surfaces, increased their rate of apoptosis, and inhibited T-cell proliferation. PMID: 15193925
31. binding site with measles virus hemagglutinin: attachment sites for MV receptors SLAM and CD46 overlap on the globular head PMID: 15308701
32. CD150 and SH2D1A are coexpressed during a narrow window of B-cell maturation and SH2D1A may be involved in regulation of B-cell differentiation via switching of CD150-mediated signaling pathways. PMID: 15315965
33. During ligation of SLAM in leprosy, signaling molecules and transcription factors participate in the induction or reinforcement of interferon-gamma production, promoting cell-mediated immune responses to mycobacterial infection. PMID: 15356162
34. activation of peripheral blood cells with agonistic anti-CD3 antibody and exogenous IL-2, as used for generation of cytokine-induced killer cells, results in significant SLAM and SAP activation 5 days after TCR stimulation PMID: 15661039
35. We have identified several novel SLAM binding sites at residues 429, 436 and 437 of measles virus haemagglutin (MVH) protein and MVH mutants in these residues dramatically decrease the ability to interaction with the cell surface SLAM. PMID: 16889684
36. SNPs present in both the SLAM and CD46 genes are associated with measurable and significant variations in antibody response after measles vaccination PMID: 17560639
37. Enhancement of anti-tumor activity in vitro and in vivo by CD150 and SAP PMID: 17692919
38. SLAM and CD46 do not have a role in measles virus growth and syncytium formation in tumor cell lines PMID: 17715217
39. Measles virus can infect and produce syncytia in human polarized epithelial cell lines independently of SLAM and CD46 by using distinctive receptor-binding sites on its hemagglutinin. PMID: 18287234
40. The functional roles of interleukin-17, SLAM and CREB on IFN-gamma production in persons with tuberculosis are reported. PMID: 19199539
41. SLAM contributes to the enhanced immunostimulatory functions of dendritic cells that are observed following the addition of IL-1 in vitro. PMID: 11489980

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HGNC: 10903

OMIM: 603492

KEGG: hsa:6504

STRING: 9606.ENSP00000306190

UniGene: Hs.523660