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SLC11A1 Antibody

  • 货号：
    CSB-PA021380LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat heart tissue
      All lanes: SLC11A1 antibody at 5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 60, 48 kDa
      Observed band size: 60 kDa
    • IHC image of CSB-PA021380LA01HU diluted at 1:300 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA021380LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC11A1 Polyclonal antibody
  • Uniprot No.：
    P49279
  • 基因名：
    SLC11A1
  • 别名：
    LSH antibody; Natural resistance associated macrophage protein 1 antibody; Natural resistance-associated macrophage protein 1 antibody; NRAM1_HUMAN antibody; NRAMP 1 antibody; NRAMP antibody; PBC antibody; SLC11A1 antibody; Solute carrier family 11 (proton coupled divalent metal ion transporters) member 1 antibody; solute carrier family 11 (sodium/phosphate symporters) member 1 antibody; Solute carrier family 11 member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Natural resistance-associated macrophage protein 1 protein (1-58AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC11A1 Antibody (CSB-PA021380LA01HU)，的标记方式是Non-conjugated。对于SLC11A1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021380LB01HU SLC11A1 Antibody, HRP conjugated ELISA
    FITC CSB-PA021380LC01HU SLC11A1 Antibody, FITC conjugated
    Biotin CSB-PA021380LD01HU SLC11A1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:100-1:300
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
  • 基因功能参考文献：
    1. important roles for c-Src tyrosine kinase in phosphorylation and activation of SLC11A1 in macrophages PMID: 29723216
    2. 3'UTR-NRAMP1 gene and VDR-Taq1 gene Polymorphisms are statistically associated with the susceptibility of TB in Andhra Pradesh Population in India. PMID: 28583097
    3. Nramp1 is expressed in microglia and neurons in the striatum of human brain and response for degrading alpha-synuclein oligomers in microglia. PMID: 28476637
    4. This study identified several important polymorphisms in the ITPKC and SLC11A1 genes in Koreans. PMID: 29214786
    5. Studied the role of natural resistance associated macrophage protein 1 (NRAMP1) polymorphisms (D543N, INT4) in pulmonary tuberculosis risk. For D543NA/G polymorphism, no associations were found in all genetic models. For INT4C/G polymorphism, significant increased PTB risk was observed in recessive model. PMID: 28648687
    6. This study shows that genetic variations in the candidate gene SLC11A1 do not affect susceptibility to cutaneous leishmaniasis in the sample population from Pakistan. PMID: 28061874
    7. in patients with non-muscle-invasive bladder cancer, the NRAMP1 D534N polymorphism could increase the risk of recurrence PMID: 29187939
    8. Taken together, this study reveals evidence demonstrating a mechanism by which the LPR6/ GSK3beta/E2F1 axis-upregulated LSH promoted gliomas. PMID: 28042322
    9. Our data suggest that the D543N variant of SLC11A1 gene has a protective effect in the development of rheumatoid arthritis in a Mexican Mestizo population PMID: 28239176
    10. The results indicated that genetic variations of D543N (rs17235409) might be associated with susceptibility to cutaneous leishmaniasis infection. PMID: 27681549
    11. SLC11A1 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    12. We found a statistical association between polymorphisms in 3'UTR region and exon 8 and CL [chi(2) = 13.26; p < 0.05; OR = 17.00; IC of 95% (2.24-128.99)]. Some patients who needed more than 40 doses of Glucantime(R) to heal injuries presented mutations in exons 3, 8, and 15. Multiple or ear lesions were not associated with NRAMP1 polymorphism. PMID: 27830154
    13. distriburtion of polymorphism allelle frequency at the INT4 region associated with oropharyngeal tularemia PMID: 27223255
    14. we conclude that presence of G allele of NRAMP1 in both rs2276631 and rs17235409 location may be a protective factor against chronic periodontitis PMID: 27309481
    15. our meta-analysis demonstrated that no significant association was identified between genetic susceptibility to UC/CD and polymorphisms of NRAMP1 gene, including (GT)n allele 2, 274 C/T, 1729+55del4 (TGTG) +/del in overall population. PMID: 27019053
    16. The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH PMID: 26658322
    17. The 274C/T polymorphism in exon 3 and the 469+14G/C polymorphism in intron 4 of the Slc11a1/Nramp1 gene were associated with susceptibility to leprosy, while the allele 2 and 3 of the (GT)n polymorphism in the promoter region were associated with susceptibility and protection to leprosy, respectively. PMID: 26814595
    18. investigation of NRAMP1, MBL, MBL, VDR gene polymorphisms and their interaction with susceptibility to pulmonary tuberculosis in a Chinese population; study suggests that genotypes of many polymorphic genes are associated with TB PMID: 26261060
    19. No significant difference was found for NRAMP1 and hGPX1 gene polymorphisms associated with recurrence time. PMID: 27069153
    20. NRAMP1 3'UTR variants were associated with susceptibility to M. tuberculosis infection. PMID: 26578819
    21. genetic association studies in population in Mexico: Data suggest an SNP in SLC11A1 (D543N, G/A genotype) is associated with treatment failure (after treatment with combinations of antitubercular agents) in male patients with pulmonary tuberculosis. PMID: 26353180
    22. Genetic variants of SLC11A1 are associated with both autoimmune and infectious diseases. PMID: 25856512
    23. SLC11A1 gene polymorphisms might have a relevant role in the pathology of leishmaniasis, directing towards susceptibility outcome of this disease PMID: 25603101
    24. Our data provide insights into the possible role of SLC11A1 variation in visceral leishmaniasis susceptibility. PMID: 25151047
    25. Nramp1 expression is up-regulated by cytokines, and its function helps to produce nitric oxide along with other pro-inflammatory responses. [Review] PMID: 26055722
    26. Study results have demonstrated, that of all investigated polymorphic variants of genes IL4 (C-590T), IL4RA (150V), TNF (G-308A) and SLC11A1 (D543N) in patients with chronic liver diseases of various etiology PMID: 26281177
    27. Highly statistically significant associations were detected between IVS4+44 C/A polymorphism in the DMT1 gene and iron and lead levels (p=0.001 and p=0.036, respectively), but no association was found with cadmium level (p=0.344). PMID: 25483413
    28. Polymorphism of the NRAMP1 gene was investigated by PCR amplification followed by RFLP analysis... patients with heterozygosity of intron 4 (GC) and/or maternal infection with helminth parasites showed reduced efficacy of BCG vaccine against tuberculosis PMID: 23408448
    29. Polymorphisms in the NRAMP1 gene, VDR gene, HLA-DRB1 gene, and HLA-DQB1 gene are statistically associated with susceptibility to TB in the Chinese Kazakh population. PMID: 24024195
    30. Study identifies SLC11A1 as a novel candidate for OM susceptibility, particularly in children with adenoids intact. PMID: 23538334
    31. Transcription factor ATF-3 regulates allele variation phenotypes of the human SLC11A1 gene. PMID: 23187734
    32. Polymorphisms in SLC11A1 were probably associated with the development of drug-resistant TB in Chinese Han population. PMID: 21457666
    33. Our findings reveal an unsuspected role for SLC11A1 in determining Clostridium. difficile pathogenicity PMID: 23690404
    34. These results suggest that the Sardinian population might be prone to develop autoimmune disease due to polymorphisms in immunomodulating the SLC11A1 gene. PMID: 23492997
    35. In the absence of LSH, the histone variant H2AX is not efficiently phosphorylated in response to DNA damage. PMID: 22946062
    36. SLC11A1-expressing lymphocytes are more prone to activation and retention of tyrosine phosphorylation, consistent with a role for inhibition of protein tyrosine phosphatases. PMID: 23509347
    37. The bactericidal activity of monocytes in patients with Reactive Arthritis is lower than that in healthy controls. The SLC11A1 274C/T and 823C/T polymorphisms may be associated with the decreased bactericidal activity of the monocytes. PMID: 23244274
    38. The T allele of rs2279014 in the 3' untranslated region of SLC11A1 was associated with protection from MAC disease when comparing allele frequencies with an odds ratio of 0.582. PMID: 22387151
    39. findings of the present study do not support the hypothesis that Nramp1...might play a role in influencing the growth of bacilli and progression of cavitary tuberculosis rather than susceptibility to M. tuberculosis infection. PMID: 23137204
    40. results suggest an association of NRAMP1 3'-UTR and D543N polymorphisms with susceptibility to mycobacterial infection in Tunisian populations in relation to age and sex PMID: 22609013
    41. This meta-analysis suggests that polymorphisms in the SLC11A1 gene contribute to TB (both pulmonary TB and extra-pulmonary TB), particularly in Asians PMID: 22326178
    42. The results shed light on the role of NRAMP1 in susceptibility to tuberculosis disease and provide a plausible explanation for NRAMP1 and MBL genetic heterogeneity in tuberculosis susceptibility. PMID: 21554230
    43. The association between sarcoidosis and four polymorphisms of the SLC11A1 gene, was investigated. PMID: 22160516
    44. Report a significant association between SLC11A1 gene variants and pulmonary tuberculosis with respect to susceptibility and subsequent disease progression in East India. PMID: 22008758
    45. Homology implies that inverted structural symmetry facilitates Slc11 H(+)-driven Me(2+) import and provides a 3D framework to test structure-activity relationships in macrophages and study functional evolution of MntH/Nramp (Slc11) carriers. PMID: 21948377
    46. No associations were observed between visceral leishmaniasis and genetic polymorphisms of SLC11A1 that were either robust to correction for multiple testing or replicated across primary and replication samples. PMID: 21599885
    47. conclude that rs3731685 (INT4) in the SLC11A1 gene may be associated with T1D susceptibility in the European ancestry population studied PMID: 21524304
    48. The 3'UTR polymorphism of NRAMP1 showed significant correlation with susceptibility to tuberculosis infection. PMID: 21710855
    49. association between SLC11A1 polymorphisms and tuberculosis susceptibility analysed by meta-analysis PMID: 21283567
    50. recruitment of the SWI/SNF complex initiated Z-DNA formation and subsequently helped to transactivate the SLC11A1 gene. PMID: 21300803

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    NRAMP family
  • 组织特异性：
    Macrophages; peripheral blood leukocytes, lung, spleen and liver.
  • 数据库链接：

    HGNC: 10907

    OMIM: 600266

    KEGG: hsa:6556

    STRING: 9606.ENSP00000233202

    UniGene: Hs.591607