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SLC12A4 Antibody

  • 货号：
    CSB-PA892363LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA892363LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA892363LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC12A4 Polyclonal antibody
  • Uniprot No.：
    Q9UP95
  • 基因名：
    SLC12A4
  • 别名：
    Electroneutral potassium chloride cotransporter 1 antibody; Electroneutral potassium-chloride cotransporter 1 antibody; Erythroid K Cl cotransporter 1 antibody; Erythroid K-Cl cotransporter 1 antibody; FLJ40489 antibody; hKCC 1 antibody; hKCC1 antibody; KCC 1 antibody; KCC1 antibody; Potassium transport protein antibody; Potassium/chloride cotransporter 1 antibody; S12A4_HUMAN antibody; Slc12a4 antibody; Solute carrier family 12 (potassium/chloride transporters) member 4 antibody; Solute carrier family 12 member 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Solute carrier family 12 member 4 protein (601-900AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC12A4 Antibody (CSB-PA892363LA01HU)，的标记方式是Non-conjugated。对于SLC12A4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA892363LB01HU SLC12A4 Antibody, HRP conjugated ELISA
    FITC CSB-PA892363LC01HU SLC12A4 Antibody, FITC conjugated
    Biotin CSB-PA892363LD01HU SLC12A4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia. Isoform 4 has no transport activity.
  • 基因功能参考文献：
    1. data indicate that Zn(2+) acting via ZnR/GPR39 has a direct role in controlling Cl(-) absorption via upregulation of basolateral KCC1 in the colon. Moreover, colonocytic ZnR/GPR39 and KCC1 reduce water loss during diarrhea and may therefore serve as effective drug targets. PMID: 28093242
    2. Insulin-like growth factors I can induce the upregulation of KCC1 gene, and KCC1 gene participates in the invasion ability of HEC-1B cells through the ERK signaling pathway. PMID: 21666489
    3. KCC3 is the dominant isoform in erythrocytes, with variable expression of KCC1 and KCC4 that could result in modulation of KCC activity PMID: 21733850
    4. human osteoblasts express functional K-Cl cotransporters in their cell membrane that seem to be able to induce the indirect activation of volume-sensitive Cl- channels by KCl through an increase in intracellular ions, water influx and cell swelling. PMID: 12637262
    5. loss-of-function KCC mutant cervical cancer cells exhibit inhibited cell growth accompanied by decreased activity of cell cycle gene products PMID: 12902337
    6. the KCC1 gene promoter lacks a TATA box and is composed of an initiator element (InR) and a downstream promoter element (DPE) PMID: 14976052
    7. Hb polymerisation and sickling could be dissociated from the abnormal response of KCC to deoxygenation observed in HbS-containing red cells. PMID: 15039017
    8. KCC activation by IGF-1 plays an important role in IGF-1 signaling to promote growth and spread of gynecological cancers. PMID: 15262997
    9. IGF-II (insulin-like growth factors-2) can enhance KCC1 (KC1 co-transport-1) gene expression in cervical cancer cells through signal transduction pathways PMID: 19317253

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    SLC12A transporter family
  • 组织特异性：
    Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular con
  • 数据库链接：

    HGNC: 10913

    OMIM: 604119

    KEGG: hsa:6560

    STRING: 9606.ENSP00000395983

    UniGene: Hs.10094