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SLC17A1 Antibody

  • 货号：
    CSB-PA021417GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q14916
  • 基因名：
    SLC17A1
  • 别名：
    Na(+)/PI cotransporter 1 antibody; Na/Pi-4 antibody; NAP 1 antibody; Napi1 antibody; NPT 1 antibody; Npt1 antibody; NPT1_HUMAN antibody; Renal Na(+)-dependent phosphate cotransporter 1 antibody; Renal sodium-dependent phosphate transport protein 1 antibody; Renal sodium-phosphate transport protein 1 antibody; Slc17a1 antibody; Sodium phosphate transporter antibody; Sodium-dependent phosphate transport protein 1 antibody; Sodium/phosphate cotransporter 1 antibody; Sodium/phosphate type I cotransporter antibody; Solute carrier family 17 (organic anion transporter) member 1 antibody; solute carrier family 17 (sodium phosphate), member 1 antibody; Solute carrier family 17 (vesicular glutamate transporter) member 1 antibody; Solute carrier family 17 member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SLC17A1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney.
  • 基因功能参考文献：
    1. A meta-analysis of all gout with Japanese, Caucasian and NZ Polynesian populations revealed that rs2285340 of SLC22A12 and rs1165196 of SLC17A1 showed a significant association but did not reach a genome-wide significance level. PMID: 27899376
    2. I269T, a common missense variant of NPT1, might have faster conformation changes than NPT1 wild type in terms of the alternating-access model of transporters, and increases renal urate export in humans. PMID: 27906618
    3. Data suggest that single nucleotide polymorphisms (SNPs) of solute carrier family 17 member 1 (SLC17A1) are potential biomarkers for altered cholesterol homeostasis and hyperhomocysteinaemia in Japanese men. PMID: 26524967
    4. Data suggest that single nucleotide polymorphisms (SNPs) rs9467596 and rs2096386 of the solute carrier family 17 (sodium phosphate), member 1 protein (SLC17A1) gene may have a correlation between hyperuricemia and alcohol drinking among Uygur patients. PMID: 26663070
    5. Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males. PMID: 26290326
    6. NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout. PMID: 25252215
    7. NPT1 is responsible for urate excretion under physiological conditions and its impairment is linked with the occurrence of gout. [review] PMID: 23876149
    8. We observed a clear effect of SLC17A1 genotype on fructose load in Europeans but not Polynesian subgroups. PMID: 23852697
    9. Renal urate transporter SLC17A1 is the third locus associated with gout at a genome-wide level of significance. PMID: 22541845
    10. results strongly suggested that NPT1 is a Cl(-)-dependent polyspecific anion exporter involved in urate excretion under physiological conditions PMID: 20566650
    11. data suggest that SLC17A1 polymorphisms are associated with the development of gout. PMID: 19556210
    12. structure and promoter activity, molecular cloning PMID: 11704559

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  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Sodium/anion cotransporter family
  • 组织特异性：
    Expressed in kidney cortex, liver and brain but not in other tissues.
  • 数据库链接：

    HGNC: 10929

    OMIM: 182308

    KEGG: hsa:6568

    STRING: 9606.ENSP00000244527

    UniGene: Hs.205816