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SLC17A3 Antibody

  • 货号：
    CSB-PA021419LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA021419LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA021419LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC17A3 Polyclonal antibody
  • Uniprot No.：
    O00476
  • 基因名：
    SLC17A3
  • 别名：
    SLC17A3 antibody; NPT4 antibody; Sodium-dependent phosphate transport protein 4 antibody; Na(+)/PI cotransporter 4 antibody; Sodium/phosphate cotransporter 4 antibody; Solute carrier family 17 member 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Sodium-dependent phosphate transport protein 4 protein (1-125AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC17A3 Antibody (CSB-PA021419LA01HU)，的标记方式是Non-conjugated。对于SLC17A3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021419LB01HU SLC17A3 Antibody, HRP conjugated ELISA
    FITC CSB-PA021419LC01HU SLC17A3 Antibody, FITC conjugated
    Biotin CSB-PA021419LD01HU SLC17A3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.
  • 基因功能参考文献：
    1. Study used rs548987 of SLC17A3 as a candidate variant of ischemic stroke and performed association analysis in a Chinese population; although rs548987 failed to show significant association with total ischemic stroke and large vessel disease subtype, the C allele of rs548987 showed significant association with small vessel disease subtype of ischemic stroke (OR=0.68, p=0.004). PMID: 27772792
    2. hNPT4 (SLC17A3) mediated time- and concentration-dependent uptake of OTxA (K(m): 802.8 microM) in a pH- and voltage-sensitive manner. PMID: 21778665
    3. variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of para-aminohippurate, bumetanide, estrone and urate; SNPs may contribute to inter-individual differences in disposition of anionic drugs and certain endogenous organic anions PMID: 21282933
    4. Genetic variants within SLC2A9,ABCG2 and SLC17A3 are associated with uric acid levels PMID: 20053405
    5. a model of urate secretion in the renal tubular cell, where intracellular urate taken up via OAT1 and/or OAT3 from the blood exits from the cell into the lumen via hNPT4. PMID: 20810651
    6. SLC17A3 seems to have a major role in determination of serum uric acid repeated measurements variation. PMID: 20162743
    7. mutation reduces the phosphate transport efficiency, possibly modulating the G6-Pase complex PMID: 15505377

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  • 亚细胞定位：
    [Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein.; [Isoform 2]: Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Sodium/anion cotransporter family
  • 组织特异性：
    Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level).
  • 数据库链接：

    HGNC: 10931

    OMIM: 611034

    KEGG: hsa:10786

    STRING: 9606.ENSP00000380250

    UniGene: Hs.327179