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SLC20A1 Antibody

  • 货号：
    CSB-PA823882LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: JK whole cell lysate, MCF7 whole cell lysate, HepG2 whole cell lysate, Hela whole cell lysate
      All lanes: SLC20A1 antibody at 1:500
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 74 kDa
      Observed band size: 74 kDa
    • Immunofluorescent analysis of HepG2 cells using CSB-PA823882LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：

    The recombinant human SLC20A1 protein (263-458aa) is used to immunize a rabbit to generate the SLC20A1 polyclonal antibody. The rabbit's immune system will recognize the immunogen as foreign and produce antibodies against it. The SLC20A1 polyclonal antibodies are purified from the rabbit's serum using protein G affinity chromatography. The purity of this SLC20A1 antibody is over 95%. This SLC20A1 antibody can be used to detect human SLC20A1 protein in ELISA, WB, and IF applications.

    The SLC20A1 protein, also known as PiT-1, mainly transports inorganic phosphate (Pi) across the plasma membrane of cells. Pi uptake via SLC20A1 is necessary for the proper functioning of various tissues and organs, including bone, kidney, and brain. Mutations in SLC20A1 have been associated with several disorders, including idiopathic basal ganglia calcification (IBGC) and some types of familial idiopathic hyperphosphatemia (FIH).

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC20A1 Polyclonal antibody
  • Uniprot No.：
    Q8WUM9
  • 基因名：
    SLC20A1
  • 别名：
    DKFZp686J2397 antibody; FLJ41426 antibody; Gibbon ape leukemia virus receptor 1 antibody; GLVR 1 antibody; GLVR-1 antibody; GLVR1 antibody; Leukemia virus receptor 1 homolog antibody; Phosphate transporter 1 antibody; PIT 1 antibody; PiT-1 antibody; PIT1 antibody; S20A1_HUMAN antibody; Slc20a1 antibody; Sodium dependent phosphate transporter 1 antibody; Sodium-dependent phosphate transporter 1 antibody; Solute carrier family 20 (phosphate transporter) member 1 antibody; Solute carrier family 20 member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Sodium-dependent phosphate transporter 1 protein (263-458AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC20A1 Antibody (CSB-PA823882LA01HU)，的标记方式是Non-conjugated。对于SLC20A1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA823882LB01HU SLC20A1 Antibody, HRP conjugated ELISA
    FITC CSB-PA823882LC01HU SLC20A1 Antibody, FITC conjugated
    Biotin CSB-PA823882LD01HU SLC20A1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification.; (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).
  • 基因功能参考文献：
    1. Targeted sequencing of two candidate genes, SLC20A1 and SLC15A4, of the solute carrier membrane transport protein family in 200 additional patients demonstrated two further variants predicted as damaging for combined hormone deficiency. PMID: 29261175
    2. Overexpression of SLC20A1 is associated with Estrogen Receptor-positive Breast Cancer. PMID: 27986439
    3. indoxyl sulfate promotes Pit-1 expression in part by activation of the JNK pathway in vascular smooth muscle cells PMID: 27001263
    4. Ox-LDL induces an osteogenic change in human aortic valve interstitial cells marked by the induction of PiT-1. PMID: 23849774
    5. Overexpression of SLC20A1 promotes apoptosis and mineralization by altering the level of Akt-1. PMID: 23308213
    6. Allelic variations in SLC20A1 were associated with the levels of Sodium-lithium countertransport. PMID: 21796222
    7. the human PiT2 histidine, H(502), and the human PiT1 glutamate, E(70),--both conserved in eukaryotic PiT family members--are critical for P(i) transport function PMID: 21586110
    8. Identification of a novel transport-independent function of PiT1/SLC20A1 in the regulation of TNF-induced apoptosis. PMID: 20817733
    9. propose that region A of Pit1 confers competence for viral entry by influencing the topology of the authentic binding site in the membrane and hence its accessibility to a viral envelope protein PMID: 12097582
    10. Two highly conserved glutamate residues critical for sodium-dependent phosphate transport are revealed by uncoupling transport function from retroviral receptor function. PMID: 12205090
    11. Our results link low-grade IL-8-mediated cartilaginous inflammation in OA to altered chondrocyte differentiation and disease progression through PiT-1 expression and sodium-dependent Pi uptake mediated by CXCR1 signaling. PMID: 15641067
    12. Phosphate uptake through Pit-1 is essential for vascular smooth muscle cell calcification and phenotypic modulation in response to elevated phosphate. PMID: 16527991
    13. Results describe the characterization of transport mechanisms and determinants critical for sodium-dependent phosphate symport of the PiT family paralogs human PiT1 and PiT2. PMID: 16790504
    14. Analysis of kinetics and substrate specificity of SLC20A1. PMID: 17494632
    15. An overexpression of Pit-1 seems to play a key role in the formation of soft tissue calcification in Werner syndrome. PMID: 18729813
    16. PiT1 depletion markedly reduces cell proliferation, delays cell cycle, and impairs mitosis and cytokinesis. PMID: 19726692

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Inorganic phosphate transporter (PiT) (TC 2.A.20) family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 10946

    OMIM: 137570

    KEGG: hsa:6574

    STRING: 9606.ENSP00000272542

    UniGene: Hs.187946