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SLC22A17 Antibody

  • 货号：
    CSB-PA910337
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA910337(SLC22A17 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8WUG5
  • 基因名：
    SLC22A17
  • 别名：
    24p3 receptor antibody; 24p3R antibody; BOCT antibody; BOIT antibody; Brain type organic cation transporter antibody; Brain-type organic cation transporter antibody; hBOIT antibody; Lipocalin-2 receptor antibody; Neutrophil gelatinase associated lipocalin receptor antibody; Neutrophil gelatinase-associated lipocalin receptor antibody; NGAL receptor antibody; NgalR antibody; NGALR2 antibody; NGALR3 antibody; OTTHUMP00000082690 antibody; OTTHUMP00000082691 antibody; Potent brain type organic ion transporter antibody; S22AH_HUMAN antibody; Slc22a17 antibody; Solute carrier family 22 member 17 antibody; Solute carrier family 22 organic cation transporter member 17 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human SLC22A17
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
  • 基因功能参考文献：
    1. Results showed the expression levels of NGAL and NGALR significantly downregulated in clear cell renal cell carcinoma samples. PMID: 30138675
    2. Biochemical and Structural Characterization of the Interaction between the Siderocalin NGAL/LCN2 (Neutrophil Gelatinase-associated Lipocalin/Lipocalin 2) and the N-terminal Domain of Its Endocytic Receptor SLC22A17. PMID: 26635366
    3. Lipocalin 2 might restore the health and regeneration potential of MSCs by decreasing senescence PMID: 24452457
    4. No significant difference was found in the expressions of NGALR mRNA in placenta among moderate preeclampsia group, severe preeclampsia group and control group. PMID: 22932106
    5. NGAL and NGALR expression might be served as novel prognostic factors and potential therapeutic targets in Hepatocellular carcinoma. PMID: 22728279
    6. This study suggested that NGAL and NGALR expression are frequently up-regulated in gliomas, and are closely associated with poor clinical outcome. PMID: 21184133
    7. These results suggested that SLC22A17, in cooperation with LCN2, to be involved in the acquisition of aggressive behavior among endometrial carcinoma cells. PMID: 21763306
    8. Neutrophil gelatinase-associated lipocalin receptor (NGALR) is differentially expressed in human glomerular disease and is significantly up-regulated by Il-1beta in HMC via MAPK/ERK activation. PMID: 21305251
    9. NGALR hypomethylation contributes to its expression in esophageal carcinomas and that this overexpression may play a role in the pathogenesis of esophageal carcinomas. PMID: 19047093

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Upon LCN2-binding, it is internalized.
  • 蛋白家族：
    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
  • 组织特异性：
    Expressed in brain.
  • 数据库链接：

    HGNC: 23095

    OMIM: 611461

    KEGG: hsa:51310

    STRING: 9606.ENSP00000206544

    UniGene: Hs.373498